良性前列腺增生患者血管内皮功能变化的临床研究  

The Endothelial Function Study of Benign Prostatic Hyperplasia

作　　者：刘岩[1] 张小民[2] 王存龙[1] 

机构地区：[1]河北医科大学附属唐山工人医院泌尿外科,河北唐山063000 [2]华北煤炭医学院附属唐山市人民医院心内科,河北唐山063000

出　　处：《苏州大学学报（医学版）》2007年第5期755-756,771,共3页Suzhou University Journal of Medical Science

摘　　要：目的研究良性前列腺增生(BPH)患者血管内皮功能的变化,探讨血管内皮功能受损与BPH的内在联系。方法检测100例BPH患者血管内皮生长因子(VEGF)、内皮素-1(ET-1)、一氧化氮(NO)、血管性假血友病因子(vWF)及前列环素(PGI2)水平,并与对照组(80名健康男性)进行比较。结果BPH组VEGF、ET-1水平均明显高于对照组,NO、PGI2水平均明显低于对照组,差异均有高度统计学意义(P<0.01);vWF水平高于对照组,但差异无统计学意义(P>0.05)。结论BPH患者血管内皮功能受损,提示血管内皮功能变化可能参与BPH的发病。Objective To investigate the relativity of benign prostatic hyperplasia and the endothelial function. Methods The levels of VEGF,ET-1,NO,vWF and PGI2 were examined in 100 cases of BPH and in 80 subjects as the controls. The differences of the two groups were compared. Results The expression of VEGF and ET-1 in BPH group was significantly higher than that in the control group, NO and PGI2 were significantly lower than that in the control group,while statistical significant difference existed between the two groups （P〈0.01）. vWF in BPH group was higher than that in the control group also, but there was no statistical significance （P〉0.05）. Conclusion The change of endothelial function plays a good role in pathogenesis and development of BPH.

关 键 词：良性前列腺增生 血管内皮功能 

分 类 号：R697.320.2[医药卫生—泌尿科学]