GC-AED联用方法分离分析12种滥用药物  

Analysis of Twelve Abused Drugs by GC-AED

作　　者：顾明松[1] 霍秀敏[1] 靳志云[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《药物分析杂志》1997年第4期221-224,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：气相色谱—原子发射光谱联用（ＧＣ—ＡＥＤ）利用微波诱导氦等离子体将经气相色谱分离的化合物分解成原子或离子，并激发发射出所含各元素的特征光谱．因微波氦等离子体具有激发所有元素的能力，所以可用于测定化合物的元素组成．由于化合物在等离子体内热解成原子或离子，其元素的响应值与原化合物的结构基本无关，因此与已知元素比例的化合物比较可测定待测物的元素比例．ＧＣ—ＡＥＤ可利用保留时间、元素组成和元素比例这３个判据进行定性分析，可提高未知物定性分析的可靠性．Twelve abused drugs were analysed by GC-AED(gas chromatography-atomic emission detector).Microwave induced-He-plasma can atomize and excite all elements in the compounds separated by gas chromatography.The element composition and ratio of these drugs were determined and the results were very similar to the theoretical values.In qualitative analysis,the retention time,element composition and element ratio were used as criteria.The detect limits were 20mg/L for element composition and 50mg/L for element ratio.Some thermolabile compounds,morphine and 6 acetylmorphine,were analysed without derivation by optimizing GC conditions.

关 键 词：滥用药物 元素分析 GC-AED 

分 类 号：R971.2[医药卫生—药品] R914.1[医药卫生—药学]