强直性脊柱炎患者HLA-B27位点等位基因相关抗原的表达  

The expression of HLA-B27 locus-associated antigens in ankylosing spondylitis

作　　者：姜玉章[1] 陈彩云[1] 刘靓[1] 

机构地区：[1]南京医科大学附属淮安市第一人民医院,淮安223300

出　　处：《中国免疫学杂志》2007年第11期1009-1011,共3页Chinese Journal of Immunology

摘　　要：目的:探讨强直性脊柱炎(AS)患者HLA-B27位点等位基因相关抗原的表达。方法:采用补体依赖性微量淋巴细胞毒法检测418例脊柱关节炎(SpAS)患者和30例正常对照HLA-B27相关抗原。结果:418例SpAS患者73例被确诊为AS,Bw6、B27(47)、B27和B7/B27/B73/B81抗原阳性率分别为31%、28%、25%和22%。在AS中,B27阳性组与B27阴性组间有不同分布,两组B27(47)、B27、B7三种等位基因有统计学意义(P<0.01)。在66例B27阳性组中,除B13与Bw6成负相关外,Bw4与B27(47)、B7与B27之间等均成明显的正相关。结论:在AS患者中,B13与Bw6、B60/61/47/48/81(13),B7与B27,Bw4与B27(47),Cw1与B42B45表达联锁失衡,B27并不是AS易感的唯一因素,其他基因位点可能起增强(如Cw1及Cw2)或抑制(如B13)AS发生的作用。Objective：To study the expression of HLA-B27 locus-associated antigens in patients with ankylosing spondylitis （AS）. Methods：The HLA-B27 associated antigens were exiamined in 418 patients with spondyloarthropathies （SpAs） and 30 controls individuals by complement dependent microcytotoxity assay. Results.There were 73 patients with AS in the SpAs. The percentage of positive Bw6, B27 （47）, B27 and B7/B27/B73/ B81 were 31%, 28 %, 25 % and 22%, respectively. In both the HLA-B27-postive group and HLA-B27-negative group, there were significantly difference among B27 alleles antigens of B27 （47）, B27 and B7. There was negatively correlation in both antigens B13 and Bw6. Conversely, there was positively correlation in both match antigens of Bw4 and B27 （47）, B7 and B27. Conclusion：There were strongly linkage disequilibrium in five match antigens of B13 and Bw6, B13 and B60/61/ 47/48/81 （13）, B7 and B27, Bw4 and B27 （47）, Cwl and B42/B45. B27 antigens are not the only a factor to determine susceptibility to AS, other alleles-associated antigens may be either enhancing, such as Cw1 and Cw2 or suppressive, on the development of AS.

关 键 词：强直性脊柱炎 HLA-B27 脊柱关节炎 

分 类 号：R392.2[医药卫生—免疫学] R593.23[医药卫生—基础医学]