重症急性胰腺炎患者抗生素相关性肠炎临床研究  

Antibiotic Associated Colitis in Patients with Severe Acute Pancreatitis:A Clinical Research

作　　者：冯刚[1] 戚仕均[1] 谢立江[1] 方泉[1] 王晋中[1] 赵萍[1] 葛剑洪[1] 赵雄碧[1] 

机构地区：[1]绍兴市中医院,浙江绍兴312000

出　　处：《中华医院感染学杂志》2007年第11期1427-1429,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析重症急性胰腺炎(SAP)患者发生抗生素相关性肠炎(AAC)的易感性和特殊性,探讨预防与治疗策略。方法回顾性分析128例SAP患者发生AAC与抗菌药物应用时间、剂量、种类的关系及疗效。结果SAP患者AAC的发生率为36.7%,与抗菌药物长期超量应用密切相关(P<0.01),以应用头孢菌素类为最高;通过调整广谱抗菌药物剂量,同时采用综合治疗方法,治愈36例,死亡11例,早期治疗AAC组平均病程和死亡率较低(P<0.05)。结论SAP患者发生AAC关键在于加强预防与综合治疗,特别是广谱抗菌药物的合理应用;早期治疗有助于缩短病程和降低死亡率。OBJECTIVE To analyze the susceptibility and specificity of antibiotic associated colitis（AAC） in patients with severe acute pancreatitis（SAP） so as to explore its prophylactic and therapeutic countermeasures. METHODS Retrospective analysis method was used to analyze the relationship between AAC incidence rate and antibiotic usage in 128 cases of SAP, including the duration, dosage, variety and curative effect of antibiotics. RESULTS The AAC incidence rate in SAP was 36, 7%, which was closely related to longtime and excessive usage of antibiotics（P^0. 01）and reached the top in using cephalosporins. After being adjusted the dosage of broad spectrum antibiotics and adoption of complex treatment, 36 cases were cured and 11 cases died. There were shorter mean course and mortality in AAC patients coped with early treatment（P〈0.05）. CONCLUSIONS It is important to strengthen prophylactic and complex treatment in SAP to avoid AAC, administer broad spectrum antibiotics reasonably, and cope with early treatment making for decrease in course and mortality.

关 键 词：重症急性胰腺炎 抗生素相关性肠炎 抗菌药物 

分 类 号：R978.1[医药卫生—药品]