药物敏感试验对泌尿生殖道支原体感染治疗作用  

Guidance Effect of Monitoring Drug Sensitivity on Treatment of Non-gonoccocal Urethritis due to Ureaplasma urealyticum

作　　者：薛文成[1] 王良民[1] 孟冬娅[1] 方秀菊[1] 陈渝宁[1] 

机构地区：[1]沈阳军区总医院,辽宁沈阳110015

出　　处：《中华医院感染学杂志》2007年第11期1433-1434,共2页Chinese Journal of Nosocomiology

基　　金：全军"十一五"科研基金资助项目(06MB048)

摘　　要：目的探讨泌尿生殖道支原体感染的临床治疗防止耐药支原体菌株产生的有效方法。方法186例患者分为A、B两组,A组97例为泌尿生殖道感染,未做过药敏试验,经验用药后临床症状不减轻而就诊者;B组89例初诊支原体感染患者;两组患者均经支原体培养确诊并做药敏试验,根据药敏试验结果用药治疗1个疗程(14 d),随访观察治疗效果。结果临床分离的支原体菌株对3大类9种药物的耐药率:四环素类、喹诺酮类药物两组间差异无统计学意义;大环内酯类药物A组患者耐药率显著高于B组;按药敏试验结果治疗1个疗程,A组97例患者中,痊愈率77.3%,显效率(以痊愈、显效患者计)88.7%;B组89例患者中,痊愈率85.4%,显效率96.6%,两组间差异无统计学意义(P>0.05)。结论不规范用药可导致支原体耐药率上升,根据药敏试验结果用药治疗支原体感染效果好、疗程短。OBJECTIVE To evaluate the guidance effect on treatment non-gonoccocal urethritis （NGU） by monitoring susceptibility of Ureaplasma urealyticum to drugs. METHODS Totally 186 outpatients were divided into two groups. Group A consisted of 97 patients with mycoplasma infection. These patients had been treated and their clinical symptoms did not eliminate or lessen. Group B included 89 patients preliminarily diagnosed as mycoplasma infection due to incubation. The secretion specimens collected from all the patients were tested by the methods of incubating and drug susceptibility all-in one. They were treated 14 days by oral administration according to results of drugs sensitive test. Therapeutic efficacy was followed up for three months. RESULTS For drug resistance of U. urealyticurn to 9 kinds of 3 species, there was no significant difference of both tetracyclines and quinolones between in groups A and B. However, the strains of Uu resistant to macrolide antibiotics were obvious higher in group A than in group B. The cure rate and CR rate were 77.3% and 88.7% in group A, and 85.4% and 96. 6% in group B. There was no significant difference between two groups （P 〉 0. 05）. CONCLUSIONS The rising rates of the drug-resistant Uu strains may be resulted of no-standard treatments. The treatment time will be shortened and the curative effects will be better if the treatments are based on the results of the susceptibility test.

关 键 词：支原体感染 耐药 治疗 

分 类 号：R375[医药卫生—病原生物学]