综合ICU慢性阻塞性肺病患者感染病原菌及药敏分析  

Bacterial Infection and Drug Resistance among COPD Patients in Comprehensive Intensive Care Unit

作　　者：杜昀泽[1] 刘林林[1] 刘慧敏[1] 

机构地区：[1]天津市人民医院,天津300120

出　　处：《中华医院感染学杂志》2007年第11期1438-1440,1451,共4页Chinese Journal of Nosocomiology

摘　　要：目的了解医院综合ICU慢性阻塞性肺病(COPD)患者感染病原菌的流行及变迁规律。方法将分离的166株病原菌分成无创、有创呼吸机及未上呼吸机3组,比较其差异。结果各组列前3位的病原菌分别为:未上呼吸机组:白色假丝酵母菌(38.8%)、克雷伯菌属(10.2%)、大肠埃希菌(8.2%);无创呼吸机组:白色假丝酵母菌(45.5%)、铜绿假单胞菌(9.1%)、克雷伯菌属(9.1%);有创呼吸机组:铜绿假单胞菌(23.2%)、白色假丝酵母菌(17.9%)、鲍氏不动杆菌(12.6%),若行机械通气耐药率明显增高。结论综合ICU COPD患者G-菌及真菌感染率高,应加强监控。OBJECTIVE To survey the distribution and diversity of bacteria among COPD patients in our hospital＇s comprehensive intensive care unit（ICU）. METHODS All 166 strains of bacteria were divided into three groups： from noninvasive positive pressure ventilation, from mechanical ventilation and from standard medical treatment and compared their difference. RESULTS The most common pathogens were Candida albicans （38.8%）, Kleb- siella pneumoniae （ 10. 2 %） and Escherichia coli （8.2 %） in the standard medical treatment group ; C. albicans （45.5%）, Pseudomonas aeruginosa （9. 1%） and K. pneumoniae （9. 1%） in the noninvasive positive pressure ventilation group ; however, P. aeruginosa （23.2 % ）, C. albicans （ 17.9 % ） and Acinetobacter baumannii （12.6 % ） in the mechanical ventilation group, respectively. Accompanying with the mechanical ventilation, the resistant- drug rates were observably increased. CONCLUSIONS The percentage of Gram-negative bacilli and fungal infection in the COPD patients of comprehensive ICU is very high. So we should supervise and control the results of antibiotics susceptibility.

关 键 词：慢性阻塞性肺病 病原菌 耐药性 机械通气 

分 类 号：R378[医药卫生—病原生物学]