儿科住院患者感染病原菌分布及耐药性分析  

Pathogenic Bacteria Distribution and Drug Resistance of Hospital Infection in Pediatrics Unit

作　　者：陈希莲[1] 朱德全[1] 

机构地区：[1]临沂市人民医院,山东临沂276003

出　　处：《中华医院感染学杂志》2007年第11期1443-1445,1448,共4页Chinese Journal of Nosocomiology

摘　　要：目的了解和探讨儿科住院患者感染的主要病原菌及耐药性现状,为临床诊断与治疗提供实验室依据。方法对2004年1月-2006年12月各类标本中检出的病原菌,采用全自动细菌鉴定仪VITEK32进行细菌鉴定和药敏试验,肺炎链球菌药敏用ATB STREP5、流感嗜血菌和黏膜炎莫拉菌药敏用ATB HAEMO进行药物敏感试验。结果凝固酶阴性葡萄球菌(CONS)108株,占分离菌的22.1%;溶血葡萄球菌58株,占凝固酶阴性葡萄球菌分离率53.7%,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)药敏结果显示多药耐药,大肠埃希菌和肺炎克雷伯菌ESBLs检出率分别为18.9%和12.5%。结论凝固酶阴性葡萄球菌已成为儿科患者感染主要病原菌,MRCNS检出率高且呈多药耐药,糖肽类抗菌药物是治疗MRCNS感染的首选药。OBJECTIVE To investigate the major pathogenic bacteria and drug resistance of hospital infection in pediatrics unit, and to provide laboratory evidence for clinical diagnosis and treatment. METHODS Pathogenic bacteria were isolated from patients who suffered from hospital infection in pediatrics unit from 2004 to 2006. the method was taken to carry out the sensitive test and bacteria identification by VITEK32, Streptococcus pneurnoni- ae, Moraxella catarrhalis and Haemophylus influenzae were assayed with French Bio-Merieux API System ATB STREP5 and ATB HAEMO, respectively. RESULTS Totally isolated strains were 489. Of them, 108 strains of coagulase negative Staphylococcus （CONS）, being 22.1%. 58 strains were S. haemolyticus. The isolated rate of CONS was 53.7%. The drug test for meticillin-resistant coagulase negative Staphylococcus （MRCNS） showed multiple drug-resistance. The detection rate of the ESBLs from the Escherichia coli and the Klebsiella pneumoniae was 18.9% and 12.5%, respectively. CONCLUSIONS MRCNS are the major pathogens in pediatrics unit. The detectable rate of MRCNS is high. Glycopeptide antibiotics are the first-choice drugs for MRCNS infection.

关 键 词：儿科患者 病原菌 耐药性 产超广谱Β-内酰胺酶 

分 类 号：R378[医药卫生—病原生物学]