2-噻吩乙醇的合成技术及其在药物中的应用  

Synthesis Techniques of 2-thiophene Ethanol and Its Application in the Medicine

作　　者：杨海玉[1] 白金[1] 李长波[1] 张洪林[1] 蒋林时[1] 

机构地区：[1]辽宁石油化工大学环境与生物工程学院,辽宁抚顺113001

出　　处：《化学与粘合》2007年第6期435-438,共4页Chemistry and Adhesion

基　　金：抚顺市科技计划项目(20052517);辽宁省教育厅高等学校科研项目(05L228)

摘　　要：介绍了重要医药中间体2-噻吩乙醇的合成方法,主要有丁基锂工艺、格氏试剂工艺、钠试剂工艺和酯还原工艺,其中,前三种路线都是以噻吩为原料,经不同的步骤得到噻吩的金属化合物,最后与环氧乙烷反应,水解得2-噻吩乙醇,酯还原工艺是以噻吩乙酸酯为原料,在催化剂作用下,将酯还原为伯醇。总结了各方法的进展状况和优缺点,并对2-噻吩乙醇在噻吩并吡啶类药物特别是盐酸噻氯匹啶和氯吡格雷中的应用及前景作了简要概述。The method for synthesis of 2 - thiophene ethanol which is an important medicine intermediate was introduced, such as butyl lithium process, Grignard process, natrium reagent process and reduction ester process. Among them, the first three routes all took thiophene as raw material, the metal compounds of thiophene could be obtained through different steps, then reacted with ethylene oxide, and finally hydrolyze into 2 - thiophene ethanol. During reduction ester process, thiophene -acetate was used as raw material, with catalyst, the ester reduced into primary alcohol. The development, advantages and disadvantages of these methods were summarized, and the prospects and application of 2 - thiophene ethanol in the medicament were also summarized, such as thienopyridine, especially ticlopidine and clopidogrel.

关 键 词：噻吩乙醇 医药中间体 合成 应用 

分 类 号：TQ710.6[化学工程]