MK-801与环境线索交互作用对吗啡行为敏感化的影响  

Interactions of MK-801 and Environmental Cues on the Behavioral Sensitization Induced by Morphine

作　　者：于斌[1] 李新旺[1] 王佳[1] 王磊[1] 任丽敏[1] 

机构地区：[1]首都师范大学教育科学学院

出　　处：《心理学报》2007年第6期1048-1054,共7页Acta Psychologica Sinica

基　　金：北京市教委科技发展计划项目(KM200710028021)成果;北京市重点实验室(学习与认知)项目;北京市重点专业(发展与教育心理学)支持项目

摘　　要：为探讨MK-801与环境线索交互作用对吗啡诱导行为敏感化的影响,将42只大鼠随机分为对照组,MK-801组,吗啡组(匹配和非匹配)和MK-801+吗啡组(匹配和非匹配)。行为敏感化模型建立分为发展期,戒断期和表达期三个阶段。实验结果发现:同时给予MK-801(0.1mg·kg-1)会促进吗啡(5mg·kg-1)诱导大鼠行为敏感化的发展,而且会使MK-801成为大鼠行为敏感化表达所必需的条件性刺激。MK-801的内部线索作用过强,从而削弱了环境的外部线索作用。研究结果表明:MK-801对吗啡诱导行为敏感化的影响存在状态依赖(state-dependency)现象,提示在NMDA受体与行为敏感化关系的研究中应考虑选择刺激特性更小的药物。Many laboratories have reported that co - administration of N - methyl - D - aspartate （NMDA） receptor antagonists such as MK - 801 with addictive drugs prevents the development of behavioral sensitization and therefore concluded that NMDA receptor transmission is necessary for sensitization. However, according to＂ State - dependency＂ interpretation, NMDA receptor antagonists do not prevent sensitization. Rather, they become a conditioned stimulus for the sensitized response. There is also considerable evidence showing that the circumstances surrounding drug administration play an important role in modulating the development and expression of the sensitization. Thus, we attempted to investigate the interactions of MK - 801 and environmental cues on the behavioral sensitization induced by morphine and determine whether the rats that receive MK - 801 ＋ morphine combination will develop state - dependency to the effect of MK - 801. 42 male Wistar rats were randomly divided into six groups： Saline, MK - 801, Morphine （paired group）, MK - 801 plus Morphine （paired group）, Morphine （unpaired group） and MK - 801 plus Morphine （unpaired group）. During the development period, each rat was administered intraperitioneally with MK - 801 （0.1mg/kg） or saline, 30 minutes later administered with morphine （5mg/kg） or saline for 7 days on end. In the paired group, the administration of morphine was performed with environmental cues （test cage） and the unpaired group received morphine without cues by replacing them into their home cage. The locomotor activities of the rats in paired group were monitored daily immediately after the second injection by using computer - interfaced monitoring system. During the expression period, all the rats were received challenge injection for three times by morphine （dayl5）, MK - 801 （dayl8） and MK - 801 plus morphine （day21） each. The distance traveled （cm） during the development period was analyzed by two - way ANOVA with treatment day as

关 键 词：吗啡 MK-801 行为敏感化 状态依赖 

分 类 号：B845[哲学宗教—心理学]