阻塞性睡眠呼吸暂停综合征与心肌缺血及心律失常临床研究  

The clinical study of obstructive sleep apnea syndrome with myocardial ischemia and cardiac arrhythmia

作　　者：马宏[1] 刘建荣[1] 周荣[1] 赵金池[1] 尤兆雄[1] 赵尚德[1] 

机构地区：[1]内蒙古医学院第四附属医院心内科,内蒙古自治区包头014032

出　　处：《中国基层医药》2007年第10期1592-1594,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：内蒙古自治区包头市卫生基金(2002G242-14)

摘　　要：目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)与心肌缺血及心律失常的相关性及危险性。方法对90例睡眠呼吸暂停综合征患者进行多导睡眠图和12导动态心电图同步监测,观察ST-T改变和期前收缩发生情况。结果OSAS患者心肌缺血总发生率为32.2%,其中重度OSAS组发生率为59.4%,中度OSAS组发生率为15.8%,轻度OSAS组发生率为20%,三组与对照组比较差异有统计学意义(P<0.01),重度与轻、中度组比较差异有统计学意义(P<0.05)。OSAS组室性期前收缩的发生率为67.7%,发生次数明显高于对照组,两组比较差异有统计学意义(P<0.05),重度OSAS组与轻、中度OSAS组比较差异有统计学意义(P<0.05)。室上性期前收缩发生次数及发生率与对照组比较,两组差异无统计学意义(P>0.05)。结论睡眠呼吸暂停综合征与心肌缺血及心律失常有较强相关性,是导致心血管疾病危险因素之一。Objective To investigate the correlation between obstructive sleep apnea syndrome（OSAS） with myocardial ischemia and arrhythmia. Methods To observe the occuring rate of premature beats and change of ST-segment,90 cases of OSAS patients were detected by the polysomnogram（PSG） and dynamic electrocardiogram at the same time. Results Total morbidity of myocardial ischemia was 32.2 % in OSAS patients,and it was 59.4 % , 15.8 % ,20 % in serious, moderate and mild groups respectively. There was a statistically significant difference between the three groups and the control group（ P 〈 0.01 ）. There was statistically difference among the serious, the moderate, and mild groups（P 〈 0. 05）. The morbidity of premature ventricular beats was 67. 7% in all OSAS groups, and there was a significant increase as compared with the control, there was a statistically difference between two groups too（P 〈 0.05 ）, while a statistically significant difference was observed as compared the serious group with the moderate and mild groups（ P 〈 0.05 ）. There was not a statistically significant difference in supraventricular premature beasts as compared the OSAS group with the control groups（ P 〉 0.05）. Conclusion As one of the risky factors of cardiovascular diseases,OSAS can induce myocardial ischemia and arrhythmia.

关 键 词：睡眠呼吸暂停综合征 心肌缺血 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病] R766[医药卫生—内科学]