不同剂量米非司酮与米索前列醇配伍对妊娠引产效果的观察  

Clinical study on termination of second-trimester gestation using different doses of combined mifepristone-miso- prostol regimen

作　　者：秦棠妮[1] 周荣向[1] 孙成玲[1] 朱庆辉[1] 朱金虎[1] 

机构地区：[1]中国人民解放军第四二一医院妇产科,广东省广州510380

出　　处：《中国基层医药》2007年第10期1624-1625,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探索合适的米非司酮剂量与米索前列醇配伍对终止妊娠的引产效果。方法选择自愿要求终止妊娠的健康孕妇180例,孕周16～24周,随机分为:米非司酮A组(米非司酮225 mg加米索前列醇)、米非司酮B组(米非司酮150 mg加米索前列醇)、依沙吖啶组,观察每组引产成功率、一次引产成功率、规律宫缩出现时间、胎儿娩出后2 h内出血量、宫颈裂伤率。结果米非司酮A组一次引产成功率高于米非司酮B组和依沙吖啶组(P<0.01),规律宫缩出现时间小于米非司酮B组和依沙吖啶组(P<0.01);胎儿娩出后2 h内出血量,米非司酮A组和米非司酮B组均少于依沙吖啶组(P<0.01);宫颈裂伤,米非司酮A组与米非司酮B组均未发生,依沙吖啶组发生2例。结论米非司酮225 mg配伍米索前列醇用于终止16～24周的妊娠,一次引产成功率及完全流产率高,引产时间短,出血少。Objective To evaluate the using of either 225 or 150 microgrammes of mifepristone combined with misoprostol for termination of second-trimester gestation（ 16- 24 weeks）. Methods 180 women requesting voluntary induced abortion during gestation 16-24 weeks were randomised to three groups,group 1 ：oral mifepristone 225mg,group 2 ：oral mifepristone 150mg, and group 3 ：injected 100mg rivanol by amniocentestis. The total success rate,once success rate, the interval of having-medicine to uterine-eonstraction, the volume of bleeding within 2 hours after labour and cervical laceration rate were observed. Results The once success rate of induced labour in group 1 was higher than that in group 2 and group 3 （P 〈 0.01 ）. The interval of having-medicine to uterlne-constraction in group 1 was shorter than that in group 2 and group 3 （P 〈0.01）. The volume of bleeding within 2 hours after labour in group 1 and group 2 was less than that in group 3（P〈0.01 ）. Two women in group 3 were found cervical laceration but none in group 1 and group 2. Conclusion The combination of mifepristone 225mg and misoprostol used for termination of second-trimester gestation（16-24 weeks） was simple, non-invasive and more effective compared with mifepristone 150mg and rivanol.

关 键 词：米非司酮 米索前列醇 依沙吖啶 引产 

分 类 号：R719.3[医药卫生—妇产科学]