下生殖道感染和IVF-ET结局关系探讨  

Study of the Relationship between the Infection of Lower Reproductive Tract and Outcome of IVF-ET

作　　者：王颖[1] 梁思群[1] 王长娟[1] 乔杰[1] 王丽娜[1] 

机构地区：[1]北京大学第三医院生殖中心,北京100083

出　　处：《生殖与避孕》2007年第11期704-709,共6页Reproduction and Contraception

摘　　要：目的:探讨宫颈感染、阴道感染与IVF-ET结局的关系。方法:回顾性分析2005年在我院生殖医学中心就诊的798例因不孕症行IVF-ET患者的液基薄层细胞检测(TCT)结果、阴道分泌物检查、HPV测定以及阴道镜和宫颈活检情况与IVF-ET过程中获卵数、胚胎质量和妊娠结局的关系。结果:798例取卵周期798个,新鲜胚胎移植周期648个,胚胎解冻移植周期588个;继续妊娠278例(34.8%),异位妊娠22例(2.7%),胚胎停育及自然流产26例(3.2%)。临床检查宫颈情况以及HPV感染情况在各种不孕原因间无统计学差异。阴道炎、HPV感染、宫颈感染以及TCT结果与IVF-ET的结局无明显关系;阴道炎类型及治疗与否、HPV感染与否、宫颈感染的程度以及TCT结果与IVF-ET过程中各个临床参数无明显关系(P<0.05)。结论:下生殖道感染与不孕症的类型、病因以及IVF-ET过程中各临床参数和妊娠结局无明显关系,不建议过度治疗HPV感染和阴道炎症而延误IVF-ET的治疗。Objective： To study the relationship among the cervix infection, vaginal infection and the outcome in Chinese women undergoing IVF-ET. Methods： In this retrospective and controlled study, 798 Chinese infertility women enrolled in an IVF from Jan 1 to Dec 31, 2005. The results of TCT, examination of vaginal leukorrhea, HPV and the number of retrieved oocytes, quality of embryo, outcome of IVF-ET were analyzed. Results： In all of the 798 patients retrieved cycle was 798, the number of embryo tranfer in fresh cycle was 648, in thaw-frozen cycle was 588; ongoing pregnant rate was 34.8%（255/798）, ectopic rate was 2.7%（22/798）, spontaneous abortion rate was 3.2% （26/798）. In our patients, there were 50 patients （6.27 %） suffering from the trichomonas, 29 patients （3.63%） from moniliasis and 46 patients （5.08%） from bacterial vaginosis. Results： There were no significant differences in the different degree of clinical sign of cervictis, mild erosion 152 patients, middle erosion 63 patients, severe erosion 19 patients and HPV 25 patients. There were no any relationship among vaginitis, HPV infection, the degree of cervictis and IVF-ET outcome; the same as the relationship among the type of vaginitis with or without treatment, HPV infection or not, the degree of cervictis, TCT results and clinical parameters in the process of IVF-ET. Conclusion： There were no any relationship among the type of infertility, cause of infertility, cervix infection, clinical parameter in the process of IVF-ET and the outcome of IVF-ET. We can give patients a treatment if they have vaginitis.

关 键 词：宫颈细胞学 IVF-ET 阴道感染 薄层细胞检测(TCT) 

分 类 号：R714.8[医药卫生—妇产科学]