抗精神病药慢性给药对大鼠海马neuregulin 1与ErbB4表达的影响  

Effects of chronic antipsychotic drug administration on the expression of neuregulin 1 and ErbB4 in rat hippocampus

作　　者：王晓东[1] 司天梅[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《中国新药杂志》2007年第21期1751-1753,1765,共4页Chinese Journal of New Drugs

基　　金：北京大学医学部"985工程"二期建设项目精神病与精神卫生学研究资金资助(985-2-027-39)

摘　　要：目的:观察抗精神病药慢性给药对大鼠海马内neuregulin 1(神经调节蛋白1,NRG1)与ErbB4蛋白表达的影响。方法:16只Wistar大鼠随机分为4组,分别腹腔注射生理氯化钠溶液、氟哌啶醇(1 mg·kg^(-1))、氯氮平(10 mg·kg^(-1))和利培酮(1 mg·kg^(-1)),qd,连续给药4周。以免疫组织化学方法检测NRG1与ErbB4在海马CA1,CA3和齿状回区的表达。结果:与对照组比较,慢性给予氟哌啶醇、氯氮平或利培酮均显著上调了海马CA3区NRG1与ErbB4的表达。氯氮平还上调了齿状回区NRG1的表达。结论:抗精神病药慢性给药增加大鼠海马NRG1与ErbB4的表达,这种改变可能与抗精神病药治疗效应有关。Objective： To determine the expression of neuregulin 1 （NRG1） and ErbB4 in rat hippocampus following chronic antipsychotic drug administration. Methods： Sixteen Wistar rats were randomly divided into 4 groups, and received intraperitoneal injections of saline （control）, haloperidol （ 1 mg·kg^-1） , clozapine （ 10 mg·kg^-1） or risperidone （ 1 mg·kg^-1 ） once daily for 4 weeks. Immunoreactivity of NRG1 and ErbB4 in the hippocampal CA1, CA3 and dentate gyrus subregions was determined by immunohistochemistry. Results： Compared to saline control, chronic administration of haloperidol, clozapine or risperidone significantly upregulated the expression of NRG1 and ErbB4 in the hippocampus. Conclusion： Chronic antipsychotic drug administration increases the expression of NRG1 and ErbB4 in rat hippocampus, which may correlate with their therapeutic effects.

关 键 词：抗精神病药 神经调节蛋白1 ERBB4 精神分裂症 

分 类 号：R965.1[医药卫生—药理学] R971.4[医药卫生—药学]