低压状态下猪鼾症模型的建立及其CT研究  

Experimental Pig Model of OSAHS under the Lower Pressure Condition and Its CT Study

作　　者：刘永义[1] 崔恒武[2] 王亚菲[3] 蔡明轩[2] 马永明[4] 

机构地区：[1]解放军第359医院耳鼻喉科,江苏镇江212001 [2]解放军第359医院放射科,江苏镇江212001 [3]镇江市第一人民医院放射科,江苏镇江212001 [4]镇江市第一人民医院五官科,江苏镇江212001

出　　处：《实用放射学杂志》2007年第11期1540-1542,1551,共4页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目(10272112)

摘　　要：目的探讨低压环境对动物上气道软组织形态学的影响。方法将试验猪置于一个低压环境饲养6个月建立猪的鼾症模型,当出现类似鼾症临床症状和鼾症相似的咽腔压力波形时,再进行CT扫描影像学检查。并与正常状态饲养的对照组进行对比。结果模型猪咽后壁及软腭明显增厚,分别为(0.94±0.16)cm和(1.06±0.23)cm;对照组分别为(0.60±0.11)cm和(0.59±0.13)cm。模型猪的气管截面积在在前、中、后部分别为(1.49±0.12)cm2、(1.37±0.32)cm2和(1.00±0.21)cm2,其中以悬雍垂水平(后部)最为狭窄;对照组前、中、后部分别为(1.30±0.14)cm2、(1.57±0.32)cm2和(2.48±0.42)cm2。结论低压状态是鼾症的重要的致病因素之一,低压状态可建立鼾症的动物模型。Objective To produce the experimental pig model of obstructive sleep apnea hypopnea syndrome（OSAHS） through raising pigs in the lower pressure container in order to study the effect of low pressure on morphology of upper respiratory soft tissue in pig. Methods The pigs were living in a container of low pressure for 6 months to make up the pig models of OSAHS. When the symptoms like OSAHS appearing and the pharyngeal respiratory pressure changing like the characteristics of OSAHS, the pigs were scanned by CT and compared with controls. Results The pharyngeal rear wall and soft palate in model pigs were thickened（0.94 cm ± 0.16 cm and 1.06 cm ± 0.23 cm respectively ） ,while in control groups were （0.60 cm ± 0.11 cm and 0.59 cm ± 0.13 cm respectively ）. The cross - sectional area of upper airway in anterior, middle and rear parts were （ 1.49 ± 0.12） cm^2, （ 1.37 ± 0.32） cm^2 and （ 1.00 ± 0.21 ） cm^2 respectively, the narrowest part was in rear area, and in control groups were （ 1.30 ± 0. 14 ） cm^2 , （ 1.57 ± 0.32 ） cm^2 and （ 2.48 ± 0.42 ） cm^2 respectively. Conclusion The lower pressure condition can be used to produce animal experimental model of OSAHS, the low pressure is the important factor to cause OSAHS.

关 键 词：动物模型 实验性 猪 阻塞性睡眠呼吸暂停低通气综合征 体层摄影术 X线计算机 

分 类 号：R332[医药卫生—人体生理学] R563.8[医药卫生—基础医学]