热碘油栓塞兔肝VX_2肿瘤血流动力学的影响  

The Influence of Lipiodol Heat-embolization on the Hemodynamics of Hepatic VX_2 Tumor in Rabbits

作　　者：张洪新[1] 曹玮[1] 李文献[1] 倪代会[1] 陈岚[1] 王珩[1] 

机构地区：[1]第四军医大学唐都医院介入放射科,陕西西安710038

出　　处：《实用放射学杂志》2007年第11期1543-1545,共3页Journal of Practical Radiology

基　　金：全军"十一五"基金面上项目(编号:06M265)

摘　　要：目的探讨热碘油栓塞兔肝VX2瘤血液动力学的影响。方法30只载VX2瘤兔,随机分为3组:A组37℃生理盐水,B组37℃碘油,C组60℃热碘油,经股动脉穿刺、兔肝动脉插管灌注或栓塞瘤血管床,1周后多普勒超声观察肿瘤血供及肝动脉、门静脉血流动力学变化,检测结果与治疗前相应血管的多普勒参数行比较。结果与A,B组相比,热碘油灌注栓塞后肝动脉血流速度降低最明显(P<0.01),阻力指数增大(P<0.05),门静脉血流速度及内径无明显变化(P>0.05);治疗后显示热碘油组瘤内及瘤周血流信号均明显减弱,部分消失(P<0.05)。结论热碘油栓塞可更有效地阻断兔肝VX2肿瘤供血,提高疗效。Objective To study the effect of lipiodol heat - embolization on the hemodynamic changes in the rabbit with VX. tumor. Methods Thirty rabbits with VX2 hepatic tumors were divided into three groups randomly（ group A,B and C）. 37℃ saline,37℃ lipiodol and 60℃ lipiodol were used in group A, B, and C respectively in embolization of VX2 via hepatic artery. The hemodynamie indexes of the tumors,hepatic artery and portal vein were recorded with color Doppler ultrasonography 1 week after perfusion, and the results were compared with those before treatment. Results The velocity of hepatic artery in group C was lowest compared with group A and C alter treatment （ P 〈 O. O1 ） ,and the resistant indexes increased （P 〈 O. 05 ）. However, the velocity and diameters of portal vein were no change compared with those before treatment （ P 〉 O. 05 ）. The blood flow signals of tumors and around tumors became less significantly and even disappeared partly after heat - embolization （ P 〈0.05 ）. Conclusion The heat - embolization with 60℃ lipiodol can block the blood supplement for hepatic VX2 tumors in rabbit effectively.

关 键 词：彩色多普勒超声 VX2瘤 肝脏 碘油 热栓塞 兔 

分 类 号：R445.1[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]