治疗慢性胆囊炎中药小复方优化的思路与方法  

Technical Lines and Methodologies for Treating Chronic Cholecystitis Using Optimized TCM Prescription

作　　者：张会宗[1] 马杰[1] 张慧颖[1] 梁茂新[2] 康廷国[2] 

机构地区：[1]辽宁省中医药研究院,沈阳110034 [2]辽宁中医药大学,沈阳110032

出　　处：《世界科学技术-中医药现代化》2007年第5期25-29,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：辽宁省教育委员会资助项目(991521129):活血排石颗粒的研制

摘　　要：目的:以治疗慢性胆囊炎中药小复方为例,探讨均匀设计与正交设计有机结合实施处方剂量配比和结构优化的思路与方法。方法:本文以特征性药效学指标为评价指标,采用均匀设计初步判定处方组成,进而利用正交设计对均匀设计优化结果进行取舍与确定。并依据不同因素自身及相互间交互作用F检验结果及各药性味主治理论,对复方内部的配伍关系加以科学诠释,对组方配伍结果做出合理判定。结果:筛选最佳处方组成及比例为赤芍15g、X17g、枳壳13g、槟榔13g、当归1.8g。结论均匀设计与正交设计相结合,可以克服两者单独为用筛选处方时各自存在的不足,从而获得最佳的筛选结果。This paper discusses the technical lines and methodologies for treating chronic cholecystitis using an optimized TCM prescription. A uniform design is made, using pharmacodynamic indexes as evaluating indexes. Orthogonal design is also used for adoption, rejection, and confirmation of the optimized results of the uniform design. The compatibility is discussed according to the interactions between different factors and indicators of prescription ingredients. Experimental results show that an optimized composition shall be the right mix of Radix Paeonlae Rvbra 15g X 17g, Fructus Aurantii 13g, Semen Arecae 13g, and Radix Angelicae Sinensis 1.8g. Authors conclude that the combined uniform design and orthogonal design can optimize both compatibility and composition of prescriptions, better than a separate application.

关 键 词：慢性胆囊炎 中药小复方 结构优化 均匀设计 正交设计 

分 类 号：R259.756.1[医药卫生—中西医结合]