骨再生修复材料的仿生制备及生物分子调控矿化  

Biomimetic Preparation of the Composite for Bone Restoration and Mineralization Modulated by the Biomolecules

作　　者：王迎军[1] 陈晓峰[1] 杨春蓉[1] 邓春林[1] 赵娜如[1] 

机构地区：[1]华南理工大学特种功能材料教育部重点实验室,广东广州510640

出　　处：《华南理工大学学报（自然科学版）》2007年第10期99-104,共6页Journal of South China University of Technology(Natural Science Edition)

基　　金：国家973项目(2005CB623902);国家自然科学基金资助项目(50472054;50672028);教育部重大科技项目(教计司【2005】4号);广东省自然科学团队基金资助项目(4205786)

摘　　要：采用冷冻干燥和纳米合成技术,仿生制备出BG-COL-HYA-PS骨修复材料,并利用体外仿生矿化实验、生物组装技术、动物体内植入实验和组织形态学观察以及扫描电镜(SEM)、能谱微区分析(EDS)、X射线衍射(XRD)等技术,对材料分别在模拟体液、培养液中以及体内的生物矿化及其调控机制进行了研究.实验表明,胶原蛋白、透明质酸、磷酸丝氨酸等生物分子作为天然细胞外基质,在调控矿化方面起到了重要作用;所制备的材料可促进骨再生修复.BG-COL-HYA-PS porous composite for bone restoration was prepared via the biomimetic method using refrigeration-desiccation and nano-synthesis techniques The mechanism of bio-mineralization and biomolecular modulation of the composite in the simulated body fluid, in the cell culture fluid and in vivo, were respectively investigated by means of the techniques such as biomimetic mineralization in vitro, bioassembly, implantation to animals, histological morphology observation, SEM/EDS and XRD. The results indicate that the natural extracellular matrixes such as collagen （COL）, hyaluronic acid （HYA） and phosphoserine （PS） play important roles in the modulation of mineralization. The prepared composite could effectively promote the new bone restoration.

关 键 词：骨修复 生物玻璃 仿生制备 生物矿化 调制 

分 类 号：TB34[一般工业技术—材料科学与工程] Q811.7[生物学—生物工程]