化痰祛瘀法对急性脑梗塞患者血浆蛋白及血栓调节蛋白的影响  

Effect of TCM Treatment for Dissolving Phlegm and Dispelling Stasis on Plasma Protein and Thrombomodulin in Patients with Acute Cerebral Infarction

作　　者：胡文忠[1] 曹锐[1] 庞宝森[1] 朱宏勋[1] 李京[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中国中西医结合杂志》2007年第11期1023-1025,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市中医药科技项目(No.JJ2003-5)

摘　　要：目的观察化痰祛瘀法治疗急性脑梗塞临床疗效及其对血浆蛋白C(protein C,PC)、蛋白S(pro-tein S,PS)、凝血酶-血栓调节蛋白(soluble thrombomdulin,TM)的影响。方法将122例患者随机分为两组,对照组60例采用内科常规方法治疗,治疗组62例在常规方法治疗的基础上同时加服化痰祛瘀汤,疗程为14日。观察两组治疗前后中医证候积分、神经功能缺损评分(NIHSS)及PC、PS、TM含量。结果治疗组中医疗效总有效率高于对照组(P=0.00);两组中医证候总积分治疗前后比较,差异有统计学意义(P=0.00),且治疗组优于对照组(P=0.037);两组NIHSS治疗前后比较,差异有统计学意义(P=0.00)。两组治疗后血浆PC、PS水平均较治疗前升高(P=0.024,0.028),且PC治疗组高于对照组(P=0.049)。结论化痰祛瘀法能明显改善急性脑梗塞患者的中医证候和神经功能缺损,提高其血浆PC、PS的水平。Objective To observe the clinical ettect ot TCM treatment lor dissolving phlegm and cllspellmg stasis （DP-DS） on acute cerebral infarction （ACI） and its influences on plasma protein C and S and soluble thrombomodulin （TM）. Methods One hundred and twenty-two patients were randomly assigned to two groups, the treated group （62 cases） and the control group （60 cases）. They were all treated with the conven- tional treatment, and DP-DS treatment was given to the treated group additionally. The treatment course was 14 days. The changes in scores of TCM syndrome and neurofunction impairment （NIHSS）, levels of plasma protein C （PC）, protein S （PS） and TM before and after treatment in the two groups were observed. Results The total effective rate of TCM syndrome in the treated group was higher than that in the control group （P = 0.00）. After treatment, NIHSS in the two groups was significantly different （P = 0.00）, and the score in the treated group was superior to that in the control group （P = 0.00）. NIHSS score and levels of PC and PS were improved in both groups （P = 0.024, 0.028）, and the improvement of PC in the treated group was superior to that in the control group respectively （P = 0. 049）. But no significant change of TM was shown after treatment. Conclusion TCM DP-DS treatment shows significant effect in improving TCM syndrome and neurofunction impairment of the patients with acute cerebral infarction, and raise the levels of PC and PS.

关 键 词：急性脑梗塞 化痰祛瘀 血浆蛋白C S 凝血酶-血栓调节蛋白 

分 类 号：R277.7[医药卫生—中医学]