血清转化生长因子β1水平在慢性乙型肝炎与乙型肝炎肝硬化患者中差异的意义  

Significance of the serum level of transforming growth factorβ1 and its difference in patients with chronic hepatitis B and HBV-induced hepatic cirrhosis

作　　者：何泽宝[1] 朱坚胜[1] 陈智[2] 朱敏[3] 曾文新[1] 陈华忠[1] 王庚歌[1] 方浩[1] 

机构地区：[1]台州医院感染科,浙江省临海市317000 [2]浙江大学医学院附属第一医院传染病研究所卫生部传染病重点实验室,浙江省杭州市310003 [3]浙江省台州医院中心实验室,浙江省临海市317000

出　　处：《世界华人消化杂志》2007年第29期3104-3106,共3页World Chinese Journal of Digestology

摘　　要：目的:观察血清转化生长因子β1(TGFβ1)水平是否与肝脏炎症、纤维化程度相关及其在慢性乙型肝炎与乙肝肝硬化患者中的差异.方法:慢性乙肝(慢性肝炎组)65例,乙肝肝硬化(肝硬化组)56例,体检健康、乙肝标志物阴性者(正常对照组)50例,均空腹采血,肝纤维化指标(HA、CⅣ、PCⅢ、LN)采用放免法测定,血清TGFβ1检测采用ELISA.结果:慢性肝炎组血清TGFβ1水平明显高于肝硬化组和正常对照组(22±13μg/L vs 10±9μg/L,11±9μg/L,P<0.01),肝硬化组血清TGFβ1水平与正常对照组相比无显著性差异(P>0.05).肝硬化组PCⅢ与血清TGFβ1水平相关(r=0.269,P=0.045),慢性肝炎和肝硬化组血清TGFβ1水平与肝功能、肝纤维化指标无明显相关性(P>0.05).结论:血清TGFβ1水平可协助诊断肝脏炎症程度与纤维化程度,但不能作为他们的判断标准.AIM： To investigate the relationship between the levels of transforming growth factor （TGF） β1 in serum and inflammation, as well as fibrous degeneration of the liver, and the difference in the levels of TGFβ1 in patients between with chronic hepatitis B and HBV-induced hepatic cirrhosis. METHODS： Four markers of hepatic fibrosis （HA, LN, CIV, PC Ⅲ） were measured by radioim- munoassay and the serum levels of TGFβ1 were measured by enzyme linked immunosorbent assay （ELISA） in 65 patients with chronic hepatitis B （chronic hepatitis group）, 56 patients with HBV-induced hepatic cirrhosis （hepatic cirrhosis group） and 50 health personnel who were negative for HBV markers （control group）. RESULTS： The serum level of TGFβ1 in the chronic hepatitis group was significantly higher than that in the hepatic cirrhosis and control groups （22 ± 13 μg/L vs 10 ± 9 μg/L, 11 ± 9 μg/L, P 〈 0.01）. The level of TGFβ1 in the hepatic cirrhosis group was similar to that in the control group. There was no correlation between the serum level of TGFβ1 and hepatic function, as well as markers of hepatic fibrosis. However, PC Ⅲ was excluded, and the coefficient of correlation between PCⅢ and serum level of TGFβ1 in the hepatic cirrhosis group （r = 0.269, P = 0.045）. CONCLUSION： TGFβ1 may play an important role in the onset of hepatic cirrhosis, and it may aid diagnosis of hepatic cirrhosis. However, there is no evidence to show that it can help establish the degree of inflammation and fibrous degeneration in the liver.

关 键 词：转化生长因子Β1 乙型病毒性肝炎 纤维化 炎症 酶联免疫吸附 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]