络脉舒通对兔心肌梗死再灌流损伤保护作用的实验研究  

Protective effect of luomaishutong on acute myocardial ischemia reperfusion injury in rabbits

作　　者：孙祎[1] 陈玉国[1] 张运[2] 徐峰[1] 李瑞建[1] 吕瑞娟[1] 薛丽[1] 张鹤[1] 

机构地区：[1]山东大学齐鲁医院急诊科,济南250012 [2]山东大学齐鲁医院心内科

出　　处：《中华急诊医学杂志》2007年第11期1160-1162,共3页Chinese Journal of Emergency Medicine

基　　金：山东省中医药管理局基金(2005046)

摘　　要：目的探讨络脉舒通对兔急性心肌梗死(AMI)再灌流损伤心脏功能和氧自由基的影响。方法新西兰大白兔24只,随机分为络脉舒通组、对照组和假手术组,每组8只,制备AMI再灌流模型。观察各组血流动力学改变,检测丙二醛(MDA)、超氧化物岐化酶(SOD)和一氧化氮合酶(NOS)的变化,测量心肌梗死面积。结果(1)与对照组相比,络脉舒通组缺血-再灌流后2h左室收缩压(LVSP)和左心室内压最大收缩和舒张变化速率(±dp/dt_(max))均显著升高(P<0.05),LVEDP则显著下降(P<0.05)。(2)对照组MDA含量比假手术组显著增高(P<0.05),而SOD和NOS活性均显著降低(P<0.05);与对照组相比,络脉舒通组心肌梗死面积显著缩小(P<0.05),心肌MDA含量显著降低(P<0.05),心肌SOD和NOS活性均显著增高(P<0.05)。结论络脉舒通具有清除氧自由基作用,可以减轻心肌再灌流损伤,改善心功能。Objective To evaluate the protective effect and mechanism of luomaishutong （LMST） on acute myocardial ischemia-repeffusion injury in rabbits. Method Twenty-four New Zealand white rabbits were randomly divided into 3 groups： the LMST group, the control group and the sham-operated group. The AMI reperfusion model was established by removing the blockade after the occlusion of coronary artery for 2 hours. The changes of hemodynamics, oxygen free radical and clearance system were measured in all rabbits. Results （1） Compared with the control group, left ventricular systolic pressure （LVSP） and maximal changing rate of left ventricular innner pressure （±dp/dtmax） increased remarkably in the LMST group after reperfusion, meanwhile, LVEDP decreased significantly. （2） In the control group, MDA level of cardiocyte was noticeably higher, while SOD and NOS levels were lower than in the sham-operated group. Compared with the control group, MDA level in the LMST group was significantly lower. Furthermore, SOD and NOS levels were higher in LMST group, and the infarcted area was smaller in the LMST group as well. Conclusions LMST can protect myocardium after ischemia-repcrfusioninjury and improve cardiac function through inhibiting induced by oxygen free radicals.

关 键 词：络脉舒通 心肌梗死 缺血-再灌流 兔 

分 类 号：R285.5[医药卫生—中药学]