原发性高血压患者血浆非对称性二甲基精氨酸浓度升高  

Plasma Asymmetric Dimethylarginine is Increased in Patients of Essential Hypertension

作　　者：王洪巨[1] 刘俊[1] 史晓俊[1] 张恒[1] 高大胜[1] 蔡鑫[1] 包宗明[1] 

机构地区：[1]安徽省蚌埠市蚌埠医学院第一附属医院心内科,安徽蚌埠233004

出　　处：《中华高血压杂志》2007年第11期930-932,共3页Chinese Journal of Hypertension

基　　金：安徽省教育厅自然科学研究项目(2006KJ398B)

摘　　要：背景非对称性二甲基精氨酸是一种内源性一氧化氮(NO)合成酶抑制剂,可以抑制NO的生成,影响血管内皮功能。目的探讨原发性高血压患者血浆非对称性二甲基精氨酸(ADMA)浓度的变化及可能意义。方法选取经冠状动脉造影检查排除冠状动脉粥样硬化性心脏病且无糖尿病的住院病人56例,其中原发性高血压(EH)患者30例,对照组(26例)为血压正常并无高血压史患者。通过高效液相色谱联合质谱法(HPLC)测定各患者的血浆ADMA、L精氨酸(L-Arg)含量,比色法测定血糖、肌酐、尿素氮、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、三酰甘油(TG)和尿酸(UA)。结果EH组血浆ADMA浓度[(0.029±0.010)mmol/L]显著高于对照组[(0.023±0.010)mmol/L,P<0.05]。两组间血浆L-Arg、HDL-C、TC、TG、UA浓度比较,差异无统计学意义(P>0.05)。血浆ADMA、L-Arg浓度与患者年龄、HDL-C、TC、TG、UA浓度无相关性(P>0.05)。结论EH患者血浆ADMA浓度升高。Background Asymmetric dimethylarginine is an endogenous nitric oxide synthetase inhibitor which inhibit the production of NO, and leading to dysfunction of vascular endothelium. Objective To investigate the alteration of plasma asymmetric dimethylarginine （ADMA） in essential hypertensive patients （EH）. Methods Thirty EH patients and 26 healthy controls were recruited. Plasma ADMA and L-Arginine （L-Arg） were measured by high performance liquid chromatography-mass spectrometry （HPLC）. Blood sugar, creati- nine, urea nitrogen, HDL-C, TC, UA and TG were assessed by colorimetry. Results The concentration of plasma ADMA in EH patients are higher than that in control （0. 029±0. 010 vs control： 0. 023±0. 010 mmol/L, P〈0. 05）. No differences were found in L-Arg, HDL-C, TC, TG, UA between them（P〉0. 05）. No rela- tionship between ADMA, L-Arg and age, HDL-C, TC, TG, UA were shown（P〉0. 05）. Conclusion The plasma ADMA concentration is increased in EH patients independent of age and the concentration of HDL-C, TC, TG.

关 键 词：非对称性二甲基精氨酸 L精氨酸 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]