葛根素对实验性代谢综合征影响的研究  

Treatment of Metabolic Syndrome with Puerarin in Rats

作　　者：赵瑛[1] 李蔚[1] 祖莹[1] 王巍[1] 

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076

出　　处：《中国药学杂志》2007年第21期1636-1639,共4页Chinese Pharmaceutical Journal

摘　　要：目的观察葛根素对实验性代谢综合征的影响。方法10%果糖水喂养Wistar大鼠6周后,检测血甘油三酯及空腹血糖、空腹胰岛素浓度,计算胰岛素敏感指数。然后腹腔注射葛根素高剂量(100 mg.kg-1)和低剂量(50 mg.kg-1),以二甲双胍为阳性对照,连续给药6周后,检测血压、口服葡萄糖耐量、葡萄糖输注率、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。结果模型组大鼠血糖升高,胰岛素敏感指数下降。葛根素干预后,与模型组比较,口服葡萄糖耐量降低,葡萄糖输注率增加(P<0.01);血压、甘油三酯、总胆固醇、低密度脂蛋白胆固醇降低,高密度酯蛋白胆固醇升高(P<0.05)。结论葛根素对果糖诱导的代谢综合征有治疗作用。OBJECTIVE To observe the effects of puerarin on metabolic syndrome （MS）. METHODS The Wistar rats were fed with 10% fructose water. Fasting blood glucose, insulin, TG were determined and the insulin sensitivity index （ISI） was calculated after 6 weeks. The rats were intravascully given puerarin high dose （ 100 mg · kg^-l ） and puerarin low dose （ 50 mg · kg^- 1 ） for 6 weeks respectirely, and dimethylbiguanide was used as positive control. The pressure, glucose infusion rate （GIR）, OGTY, TC, TG, HDL- C, LDL-C were determined after administration. RESULTS The blood glucose of rats in model group was increased and ISI was decreased. Compared with the rats in model group , OGTY in Puerarin high dose group and puerarin low dose group was decreased, GIR was increased （P 〈 0. 01 ） , blood pressure, TC, TG, LDL-C were decreased and HDL-C was increased （P 〈 0. 05 ）. CONCLUSION Puerarin can treat MS induced by fructose.

关 键 词：葛根素 代谢综合征 葡萄糖输注率 动物模型 

分 类 号：R965[医药卫生—药理学]