重型肝炎患者血清肝炎病毒标志的检出及与预后的关系  

THE DISTRIBUTION OF UL 30 GENE FRAGMENT OF HERPES SIMPLEX VIRUS Ⅰ IN HUMAN ORAL SQUAMOUS CELL CARCINOMA

作　　者：林炳亮[1] 杨绍基[1] 姚集鲁[1] 

机构地区：[1]中山医科大学附属第三医院传染病科

出　　处：《中山医科大学学报》1997年第3期208-209,212,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：用酶联免疫吸附试验（ＥＬＩＳＡ）和聚合酶链反应（ＰＣＲ）技术对２０３例重型肝炎的血清肝炎病毒标志物进行检测，结果显示单纯ＨＢＶ感染１０８例（５３．２％），ＨＣＶ感染６例（２．９５％），ＨＥＶ感染８例（３．９４％），ＨＢＶ和ＨＣＶ混合感染１７例（８．３７％），ＨＢＶ和ＨＥＶ混合感染３６例（１７．７３％），１２例（５．９１％）未找到确切病因，表明ＨＢＶ感染仍是重型肝炎的最主要病因（１７６／２０３），其次为ＨＥＶ感染（５０／２０３），ＨＣＶ感染排第三。本文尚观察到ＨＢＶ混合ＨＥＶ感染病死率高。The UL30 gene fragment of Herpes Simplex Virus Ⅰ(HSV Ⅰ) was detected by in situ hybridization technique in four cases of invasive oral squamous cell carcinoma (SCC) without metastasis,four cases of invasive oral SCC with metastasis and their metastatic lymph node tissues.The results showed :(1) The UL30 gene fragment was distributed in four cases of oral SCC without metastasis,three cases of oral SCC with metastasis and their metastatic lymph node tissues (P>0.05);(2)The UL30 gene fragment was located mainly in tumor epithelial cell cytoplasms;(3) The UL30 gene fragment retained persistantly in epithelial cells during invasion and metastasis of SCC;(4) The tissues with positive hybridization signals did not show the morphologic features of HSV Ⅰproductive infection.The results implied that HSV Ⅰmay play special roles in oral cancer development by a unique form of infection.

关 键 词：肝炎 肝炎病毒 聚合酶链反应 方法 预后 

分 类 号：R512.607[医药卫生—内科学] R373.21[医药卫生—临床医学]