NMDA受体对纹状体长时程增强和强直刺激后c-fos表达的影响  

Effects of NMDA receptor on striatal long-term potentiation and c-fos expression induced by high frequency stimulus

作　　者：周蓉[1] 崔胜忠[1] 谢桂琴[1] 陈玲[1] 袁孝如[1] 

机构地区：[1]南京医科大学生理学系,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2007年第11期1205-1208,F0002,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30572173;30370449);江苏省高校自然科学基金(06KJB180071);南京医科大学科技发展基金(NY0509)

摘　　要：目的:观察NMDA受体对强直刺激后纹状体长时程增强和c-fos表达的影响。方法:采用纹状体离体脑片细胞外记录电生理技术和免疫组化技术。结果:NMDA受体的拮抗剂MK-801(20μmol/L)完全抑制了长时程增强的产生以及强直刺激后c-fos的表达。结论:NMDA受体参与了纹状体长时程增强的过程和强直刺激后c-fos的表达。Objective：To investigate the effects of NMDA receptor on the long term potentiation （LTP） and c-fos expression induced by high frequency stimulus, in rat striatum in vitro. Methods：Both extracellular field potential recording and immunochemistry method were used in the study. Results：The results showed that LTP was inhibited by NMDA receptor antagonist MK-801 （20μmol/L） completely, and that activation of c-fos induced by tetanic stimulus in the same slices was inhibited. Conclusion：The present results demonstrated that NMDA receptor was involved in LTP and c-fos expression after tetanic stimulation.

关 键 词：长时程增强 NMDA受体 MK-801 C-FOS 纹状体 

分 类 号：R338.2[医药卫生—人体生理学]