FK506致肝功能异常2例并文献复习  

Fk506 caused 2 cases liver damage after kidney transplantation and review of literature

作　　者：李金庆[1] 马潞林[2] 赵磊[2] 张树栋[2] 候小飞[2] 王国良[2] 罗康平[2] 

机构地区：[1]青岛大学医学院第二附属医院泌尿外科,青岛266042 [2]北京大学第三医院泌尿外科

出　　处：《临床医学》2007年第11期5-7,共3页Clinical Medicine

摘　　要：目的探讨FK506的肝毒性。方法报告2例肾移植术后应用FK506后,出现转氨酶、胆红素升高。结果1例仅停药后肝功恢复;另1例经停药,保肝治疗后恢复。结论FK506可引起肝脏损害,致转氨酶、胆红素升高,临床应用中注意该项副作用。Objective To discuss the drug - induced liver damage by FKS06. Methods Clinical data of 2 cases whose alanine aminotransferase（ALT）, bilirubin （T- Bil ） elevating with oral take FKS06 after renal transplantation had been analysed. Results One patient＇s hepatic function had returned normal after stopping FK.506; the other had returned normal after stopping FKS06 and giving liver - protective remedies. Conclusion FKS06 may cause liver damage and liver function, so they should be monitored in renal recipients particularly.

关 键 词：FK506 肝毒性 药物副作用 

分 类 号：R595.3[医药卫生—内科学]