支气管哮喘患者血浆白细胞介素-5、白细胞介素-10水平的变化  

An observation of plasma of interleukin-5 and interleukin-10 concentrations in asthmatic patients

作　　者：刘领[1] 赵淑敏[1] 卢青[1] 薛兵[1] 李秀业[1] 杨霁[1] 吴文杰[1] 

机构地区：[1]北京市垂杨柳医院呼吸科,100022

出　　处：《临床内科杂志》2007年第11期752-754,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨反映哮喘气道炎症的客观指标。方法采用酶联免疫吸附法分别于急性期和缓解期对43例哮喘患者进行血浆白细胞介素-5(IL-5)、白细胞介素-10(IL-10)浓度测定,并与对照组比较。哮喘患者同期行肺通气功能检查,观察IL-5/IL-10与FEV1%、PEEF的关系。结果与对照组比较,哮喘患者血浆IL-5浓度增高而IL-10浓度降低,差异均有显著性(P值均<0.05)。急性期哮喘患者血浆IL-5浓度比缓解期增高,而IL-10浓度低于缓解期,差异具有显著性(P值均<0.05)。急性期IL-5/IL-10与FEV1%、PEEF呈负相关,相关系数分别为-0.6125和-0.5147(P值均<0.05)。结论IL-5、IL-10水平变化参与了哮喘发病,其检测有助于哮喘气道炎症状态的评估。Objective To find objective markers reflecting airway inflammation in asthmatic patients. Methods Plasma concentrations of intedeukine-5 （ IL-5 ） and interleukine-10 （IL-10） were measured by ELISA in acute and relief period of 43 asthmatic patients respectively and 20 health persons as well. The relationship between IL-5/ IL-10 and index of FEV 1% and PEEF in acute period of asthma was also assessed. Results Plasma level of IL-5 significantly increased in asthmatic patients compared with health subjects （P 〈0.05） ,and it was also significantly ldgher in acute period than that in relief period. On contrast,plasma level of IL-10 is significantly lower in asthmatic patients （P 〈 0.05 ） ,and lower in a- cute period （ P 〈 0.05 ）. Meanwhile, negative correlation between IL-5/IL-10 and index of FEV： % and PEEF were also noticed （ P 〈 0.05 ）. Conclusions Changes of IL-5 and IL-10 involve possibly in pathogenesis of asthma, and detection of them is worthy for evaluating airway inflammation in asthmatic patients.

关 键 词：支气管哮喘 白细胞介素-5 白细胞介素-10 

分 类 号：R562.25[医药卫生—呼吸系统]