氧化锌乳膏的制备及质量控制  

Preparation and Quality Control of ZnO Cream

作　　者：王栋[1] 郭珉[1] 麻世泽[1] 韩国柱[2] 

机构地区：[1]大连市皮肤病医院药剂科,大连市116021 [2]大连医科大学药学院,大连市116027

出　　处：《中国药房》2007年第34期2686-2687,共2页China Pharmacy

摘　　要：目的:制备氧化锌乳膏并建立其质量控制方法。方法:以水包油(O/W)型基质制备乳膏;采用乙醇-氯仿(1∶1)溶解基质,用乙二胺四醋酸二钠溶液滴定法测定其中主药的含量。结果:所制备乳膏涂展性好,性状、鉴别、检查等均符合2005年版《中国药典》相关规定;其主药含量约为16%。结论:本制剂制备工艺简单,质量控制方法可靠,制剂质量稳定。OBJECTIVE： To prepare ZnO cream and to establish its quality control method. METHODS： The O/W cream base was used to prepare ZnO cream; The ZnO cream was assayed by EDTA - Na2 titration method with C2H5OH - CHCl3 （1 ： 1） to dissolve cream base. RESULTS： The prepared ZnO cream was well -spread, and its property, identification and tests etc were all in conformity with the description of China Pharmacopeia （2005 edition） . The content of the ZnO stood at 16%. CONCLUSION： The preparative procedure of ZnO cream was simple and practicable, its quality control method was reliable and its quality was stable.

关 键 词：氧化锌乳膏 制备 质量控制 

分 类 号：R927.11[医药卫生—药学]