孕产妇乙型肝炎病毒对子代性别比例失调的影响  

Hepatitis B Virus in Pregnant Women-the Influence on Sex Ratio of the Offspring

作　　者：何宗忠[1] 王强[2] 任均田[3] 宋梅[3] 裘宇容[2] 

机构地区：[1]南方医科大学研究生学院,广州510515 [2]南方医科大学南方医院检验科,广州510515 [3]解放军第157医院,广州510510

出　　处：《热带医学杂志》2007年第11期1100-1102,共3页Journal of Tropical Medicine

摘　　要：目的探求乙型肝炎病毒(HBV)对出生性别比例(sex ratio at birth,SRB)失调的影响,以便为解决SRB持续偏高提供参考信息及理论依据。方法回顾性调查分析在解放军第157医院妇产科住院的4480位产妇的HBV与孕产次情况,以及她们分娩的4513名活婴的SRB情况。结果在4513个活婴中,SRB为121.88;孕1产1产妇的子代SRB为111.45,非孕1产1的子代SRB则为128.14,95%的可信区间分别为98.02～119.63、115.24～134.30,两者之间的差异有统计学意义(!2=4.617,P=0.032)。HBV正常组子代SRB为112.18,HBV携带组则为173.76,95%的可信区间分别为104.79～119.30、143.68～203.84,两者之间的差异有统计学意义(x2=21.892,P<0.001);在孕1产1这部分产妇分娩的子代中,HBV正常组SRB为103.90,HBV携带组则为148.78,95%的可信区间分别为92.71～114.78、107.14～190.42,两者之间的差异有统计学意义(x2=5.610,P=0.018)。结论HBV是影响SRB失调的疾病因素之一,是SRB失调的非社会性因素。Objective To explore the influence of the hepatitis B virus （HBV） on sex ratio at birth （SRB）, and to make recommendation to solve the sex ratio imbalance. Methods 4 480 pregnant women in the Gynecology and Obstetrics Department, The Chinese People＇s Liberation Army 157th Hospital, and also their newborn infants （4 513） were retrospectively analyzed. Results Among the 4 513 newborn infants, the SRB was 121.88 males / 100 females. For the parturient women （first pregnancy, and with 1 newborn）, the SRB was 111.45, the 95% confidence interval （CI） was 98.02-119.63. For the other parturient women, the SRB was 128.14（95% CI was 115.24-134.30）. The difference of SRB in these 2 groups of women was significant （X^2=4.617,P=0.032）. The HBV carrier group had offspring sex ratios of 172.06 boys / 100 girls （95% CI was 143.68-203.84）. In contrast, the SRB of the group with non-HBV was 112.18 （95% CI was 104.79-119.30）. The difference of SRB in these 2 groups was highly significant （X^2=21.892,P〈0.001）. Among the parturient women （first pregnancy, and with 1 newborn）, HBV carriers had offspring sex ratio of 148.78 boys / 100 girls （95% CI was 107.14-190.42）. In contrast, the SRB in the non-HBV carrier group was 103.90 （95% CI was 92.71-114.78）, the difference was also statistically significant （X^2=5.610,P= 0.018）. Conclusion HBV is one of the non-social factors which influences the sex imbalance.

关 键 词：乙型肝炎病毒 出生性别比例 子代 失调 

分 类 号：R512.62[医药卫生—内科学]