雷公藤T_4、T_7单体对大鼠生精细胞染色体和微核的影响  

Effect of T 4 and T 7 , compounds isolated from Tripterygium wilfordii, on the rates of chromosome aberration and micronuclei formation in spermatogenic cells of male rats

作　　者：刘启兰[1] 许烨[1] 钱绍祯 

机构地区：[1]江苏省计划生育科学技术研究所

出　　处：《男性学杂志》1997年第2期89-91,共3页

摘　　要：本文采用体内给药的方法，研究了雷公藤中抗生育有效化合物Ｔ４、Ｔ７在抗生育剂量下，对ＳＤ雄性大鼠生殖细胞染色体畸变率和微核形成的影响。大鼠口服Ｔ４抗生育剂量为每日８０μｇ／ｋｇ，Ｔ７为３１７μｇ／ｋｇ，１０周后制片分析，并与对照组比较，发现染色体畸变平均值各组之间的差异没有统计学意义（Ｐ＞０．０５），各组之间的生精细胞微核出现率也无统计学意义（Ｐ＞０．０５）。结果表明，雷公藤中抗生育有效成分Ｔ４、Ｔ７单体对大鼠精原细胞染色体的细胞遗传学效应和生精细胞微核发生率的影响结果是一致的，也提示抗生育剂量的Ｔ４和Ｔ７无明显的诱变作用。由于Ｔ７的各项指标更接近对照组，我们认为Ｔ７优于Ｔ４。The present study was to investigate the effects of antifertility doses of T 4 and T 7 on the occurrence of chromosome aberration and micronuclei formation in spermatogenic cells of male SD rats. The rats were given orally either T 4 80 μg/kg·d -1 or T 7 317 μg/kg·d -1 for 10 weeks. After that the chromosome aberration and micronuclei rates were examined and compared with those of the control group. It was shown that there were no significant difference in these parameters between the two groups and between either group and the control ( P >0.05). However the data of T 7 were closer to those of the control. Results suggested that both T 4 and T 7 did not damage the genetic material, while T 7 might be better than T 4 in this respect.

关 键 词：雷公藤单体 微核 染色体 生精细胞 大鼠 

分 类 号：R285.5[医药卫生—中药学]