复方丹参注射液对实验性肝损伤小鼠的保护作用  

Protective Effects of Compound Salvia Miltiorrhiza Bunge on Experimental Liver Injury

作　　者：孙沛毅[1] 张洪泉[1] 孙云[1] 林安平[1] 钱涯邻[2] 

机构地区：[1]扬州大学医学院 [2]扬州苏北人民医院

出　　处：《南京铁道医学院学报》1997年第2期93-94,共2页Journal of Nanjing Railway Medical College

摘　　要：研究复方丹参注射液对实验性肝损伤小鼠的保护作用及其机制。方法：采用急性肝损伤模型，观察小鼠血浆和肝匀浆过氧化脂质（ＬＰＯ）、血浆丙二醛（ＭＤＡ）含量及血清酶学改变。结果：复方丹参注射液防治组与对照组相比，小鼠肝损伤明显减轻，血浆和肝匀浆ＬＰＯ、ＭＤＡ含量下降，血清ＧＰＴ、ＧＯＴ降低，降低程度与用药量呈明显的量效关系。结论：复方丹参注射液对小鼠实验性肝损伤具有保护作用，其机制与抑制脂质过氧化反应有关。Objective:To study the effect of compound injection Salvia miltiorrhiza Bunge (SMB.CO.Inj) on experimental hepatic damage of mice.Method:An acute liver injury model was used.Lipid peroxide(LPO) in plasma and liver homogenate,plasma melondialdehyde(MDA),glutamic-pyruvic transaminase(GPT) and glutamic-oxaloacetic transminase(GOT) in mice were observed and compared with those of control groups.Result:As compared with the control groups,SMB.CO.Inj. dose-dependently inhibits experimental hepatic damage and the abnormally increased of LPO in plasma and liver homogenate,as well as plasma MDA,GPT and GOT.Conclusion:SMB.CO.Inj has a protective effect on experimental hepatic damage in mice and it is related to inhibition of lipid peroxidation.

关 键 词：肝损伤 过氧化脂质 丙二醛 复方丹参注射液 

分 类 号：R285.5[医药卫生—中药学]