二甲基甲酰胺对肝脏钙稳态影响的实验研究  

Expermental Investigation of Dimethylformamide on Calcium Homeostasis of Rat Liver

作　　者：阚宝甜[1,2] 乔赐彬 

机构地区：[1]山东医科大学附属医院内科 [2]山东省劳动卫生职业病研究所

出　　处：《中国公共卫生学报》1997年第3期180-182,共3页

摘　　要：采用二甲基甲酰胺短期染毒实验方法观察了它对肝脏钙稳态的影响。结果表明，二甲基甲酰胺可明显降低线粒体、微粒体对钙离子的转运能力，抑制Ｃａ２＋－ＡＴＰａｓｅ活力，使胞浆中钙离子浓度升高。病理及超微结构观察示它可致肝细胞损伤甚至坏死，其损伤的主要部位在线粒体及内质网。In this paper short term Dimethylformamide administration was used to observed the influence of Dimethylformamide on rat liver calcium homeostasis.The result showed that Dimethylformamide could decrease the ability of Ca 2+ transport by mitochondria and microsome,inhibited the ativity of liver Ca 2+ ATPase and increared the activity of phosphorylase a.Pathological and ultrastructure observation showed that Dimethylformanide could cause rat liver cells parenchymatous degeneration and necrosis.Mitochondria and microsome were damaged seriously.

关 键 词：二甲基甲酰胺 肝脏 线粒体 微粒体 钙稳态 

分 类 号：R992[医药卫生—毒理学]