有机氯农药雄性生殖毒性中MAPK信号转导途径的作用机制  

Mechanisms of mitogen-activated protein kinase pathway in male reproductive toxicity induced organochlorine pesticides

作　　者：于海歌[1] 杨克敌[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室,武汉430030

出　　处：《卫生研究》2007年第6期756-758,762,共4页Journal of Hygiene Research

基　　金：国家自然科学基金项目(No30671734);国家重点基础研究发展计划(国家973项目)(No2002CB512908)

摘　　要：促有丝分裂原活化蛋白激酶(MAPK)信号传导途径与细胞生长、分化、凋亡等密切相关,在介导细胞凋亡过程中起着重要作用。近年研究发现MAPK途径在调控有机氯农药诱导雄性生殖毒性中发挥了极为重要的作用,并且发现活性氧的大量生成是介导有机氯农药作用于MAPK途径的关键性物质。探讨有机氯农药诱导细胞凋亡的发生发展与MAPK信号途径关系,有助于从分子水平上深入的阐明有机氯农药诱导雄性生殖障碍的作用机制。Mitogen-activated protein kinase pathway may closely associated with cell growth, differentiation and apoptosis, it may play an important role in cell death. With growing evidences from in vitro test, recently it demonstrated that the MAPK play a key role in the reproductive toxicity induced organochlorine pesticides and also showed that the products of Reactive Oxygen Species （ROS） induced organochlorine pesticides in these process. The relationship between MAPK and their activation results in apoptosis induced organochlorine pesticides, for further clarification of the mechanism of male reproductive toxicity induced organochlorine pesticides.

关 键 词：有机氯农药 促有丝分裂原活化蛋白激酶 雄性 生殖毒性 环境毒理学 

分 类 号：R994.6[医药卫生—毒理学] S482.32[医药卫生—药学]