以血小板减少为主要表现的肾综合征出血热的临床特征  

Analysis on the Manifestations of Hemorrhagic Fever with Renal Syndrome(HFRS) Manifested with Thrombocytopenia

作　　者：易彦[1] 龚凡杰[1] 阳盛[1] 陈孟君[1] 赵云[1] 

机构地区：[1]中南大学湘雅二医院血液科,湖南长沙410011

出　　处：《医学临床研究》2007年第8期1255-1256,1261,共3页Journal of Clinical Research

基　　金：湖南省自然科学基金项目(06CD034)

摘　　要：【目的】分析以血小板减少为主要表现的肾综合征出血热(HFRS)的临床及实验室检查特点,以提高诊断水平。【方法】分析40例HFRS的临床特征并检测其外周血象、T淋巴细胞亚群以及骨髓像。【结果】发热、肾功能异常或尿蛋白阳性、异型淋巴细胞见于大多数患者;患者血小板常显著降低,但出血倾向不明显,血小板常在2周左右恢复正常;骨髓中巨核细胞存在成熟障碍和T淋巴细胞亚群异常见于大多数HFRS患者。【结论】以血小板减少为主要表现的HFRS患者,具有不典型的HFRS的其他症状;HFRS患者血小板虽明显降低但出血倾向不明显,不需积极的升血小板治疗;骨髓中巨核细胞成熟障碍和T淋巴细胞亚群的异常常见于HFRS患者,但其对HFRS的诊断意义不大。[Objective]To improve the diagnosis on hemorrhagic fever with renal syndrome （HFRS） manifested with thrombocytopenia, analyze the clinical and laboratory manifestations. [Methods]Analysis on the clinical and laboratory feature of the patients was made. [Results]Most of the patients had fever, with renal disfunction or urine protein and depressed platelet count, which upgraded in two weeks, without severe bleeding tendency. Atypical lymphocyte, dysmaturity of the megalocaryocyte and abnormal subgroup of T lymphocyte appeared in most of the patients. [Conclusion]HFRS patients manifested with thrombocytopenia possess other atypical HFRS manifestions, which should be helpful to the HFRS diagnosis, while dysmaturity of the megalocaryocyte and abnormal subgroup of T lymphocyte didn＇t be helpful in the diagnosis. Treatment to heighten platelet is not required for the HFRS manifested with thrombocytopenia.

关 键 词：肾综合征性出血热 血小板减少 

分 类 号：R512.8[医药卫生—内科学]