硝酸异山梨醇酯对内皮素、一氧化氮的影响及对哮喘的治疗作用  

EFFECTS OF INHALATED ISOSORBIDE DINITRATE ON ENDOTHELIN AND NITRIC OXIDE AND ITS THERAPEUTIC EFFICACY FOR EXPERIMENTAL GUINEA PIGS WITH ASTHMA

作　　者：向旭东[1] 周淮英 姚蔚[1] 

机构地区：[1]广西北海市人民医院内科

出　　处：《湖南医科大学学报》1997年第3期220-222,共3页Bulletin of Hunan Medical University

摘　　要：为探讨硝酸异山梨醇酯雾化吸入对支气管肺泡灌洗（ＢＡＬ）液中内皮素（ＥＴ）、一氧化氮（ＮＯ）水平的影响及对哮喘的治疗作用，用卵蛋白复制豚鼠哮喘模型，观察其ＢＡＬ液中ＥＴ和ＮＯ水平及气道的病理变化；结果发现硝酸异山梨醇酯能分别升高和降低哮喘豚鼠ＢＡＬ液中的ＮＯ水平及ＥＴ水平，并使其气道的炎症反应减轻。提示硝酸异山醇酯雾化吸入有利于哮喘的治疗。To probe into the correlation between the changes of endothelin and nitric oxide in bronchial alveolar lavage fluid (BALF) and the treatment of inhaling isosorbide dinitrate on experimental guinea pigs with asthma, we divided 25 guinea pigs randomly into three groups (Control group, Asthma group, Isosorbide dinitrate group), and induced some subjects by inhalation of aerosolized ovalbumin as the model of asthma to investigate the endothelin (ET) and nitric oxide (NO) level in BALF as well as the pathological change of the respiratory tract. We found that the level of endothelin and nitric oxide in BALF were all elevated in experimental guinea pigs with asthma, but the degree of increase of NO in BALF was lower than that of ET. The NO and the ET levels in BALF were negative correlation (r=-0.8050,P<0.01). After having been treated with aerosolized isosorbide dinitrate, the NO level in BALF was significantly elevated and the ET level in BALF was decreased in comparison with the asthma group (P<0.001, respectively). Moreover, the eosinophile infiltration, exoserosis, and epithalaxia of the respiratory tract of the guinea pigs were all lightened. The results suggest that inhaled isosoratory dinitrate could be used for treating asthma, and its mechanism may be elevation of NO level and decrease of ET level in BALF.

关 键 词：哮喘 药物疗法 硝酸异山梨醇酯 内皮素 一氧化氮 

分 类 号：R562.250.5[医药卫生—呼吸系统]