Synthesis and Study of Antidiabetic Properties of the Neodymium Complexes with N^5-[o-（un）Substituted Benzoyl]-N^1,N^1 - dimethylbiguanide  

作　　者：段宗炼 曾正志 

机构地区：[1]College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2007年第12期1919-1923,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20171019）.

摘　　要：N^1,N^1-Dimethylbiguanide hydrochloride （HDMBG,HCl） was introduced as an oral glucose-lowering agent to treat non-insulin dependent diabetes mellitus. In this paper, two solid complexes-trichlorotris（N^5-benzoyl-N^1,N^1-dimethylbiguanidato）neodymium, [Nd（BDMBG）3Cl3）, and chlorobis-[N^5-（o-carboxybenzoyl）-N^1,N^1- dimethylbiguanidato]neodymium, [Nd（CDMBG）2Cl], were synthesized and characterized by elemental analyses, fluorescence spectra, IR, UV, DG, DTA etc. Biological testings were conducted by diabetic rats and ESR. The results showed that both the antidiabetic activity and the inhibition rates （Ih） to superoxide anion free radical （O2） on lipid are in the order as follows： Nd（SDMBG）3 [tris（N^5-salicyloyl-N^1,N^1-dimethylbiguanidato）neodymium]〉 Nd（CDMBG）2Cl≈HDMBG·HCl 〉Nd（BDMBG）3Cl3. It was concluded that different substituents at the o-position of the benzoyl group may affect these two kinds of behaviour to a great extent.N^1,N^1-Dimethylbiguanide hydrochloride （HDMBG,HCl） was introduced as an oral glucose-lowering agent to treat non-insulin dependent diabetes mellitus. In this paper, two solid complexes-trichlorotris（N^5-benzoyl-N^1,N^1-dimethylbiguanidato）neodymium, [Nd（BDMBG）3Cl3）, and chlorobis-[N^5-（o-carboxybenzoyl）-N^1,N^1- dimethylbiguanidato]neodymium, [Nd（CDMBG）2Cl], were synthesized and characterized by elemental analyses, fluorescence spectra, IR, UV, DG, DTA etc. Biological testings were conducted by diabetic rats and ESR. The results showed that both the antidiabetic activity and the inhibition rates （Ih） to superoxide anion free radical （O2） on lipid are in the order as follows： Nd（SDMBG）3 [tris（N^5-salicyloyl-N^1,N^1-dimethylbiguanidato）neodymium]〉 Nd（CDMBG）2Cl≈HDMBG·HCl 〉Nd（BDMBG）3Cl3. It was concluded that different substituents at the o-position of the benzoyl group may affect these two kinds of behaviour to a great extent.

关 键 词：N^5-benzoyl-N^1 N^1-dimethylbiguanide neodymium complex anti-diabetes ANTIOXIDATION 

分 类 号：O6[理学—化学]