肺炎支原体肺炎患儿血清白细胞介素-10、转化生长因子-β1检测的意义  

Significance of Interleukin-10 and Transforming Growth Factor-beta 1 Detection in Children with Mycoplasma Pneumoniae Pneumonia

作　　者：蔡建敏[1] 陈同辛[2] 王振海[1] 周鸿烈 

机构地区：[1]上海市第六人民医院金山分院儿科,上海201500 [2]上海交通大学医学院附属新华医院上海市儿科医学研究所免疫室,上海200092

出　　处：《实用儿科临床杂志》2007年第4期256-257,共2页Journal of Applied Clinical Pediatrics

基　　金：上海市金山区卫生局科研基金项目资助(2003007)

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿急性期及恢复期外周血IL-10、转化生长因子-β1(TGFβ-1)水平变化的临床意义。方法采用双抗体夹心酶联免疫吸附法(ELISA)测定26例MPP急性期和其中恢复期9例患儿及12例健康儿童血清IL-10、TGFβ-1水平。比较MPP急性期与恢复期IL-10、TGFβ-1的差异。结果MPP急性期及恢复期患儿血清IL-10水平均显著低于对照组(P<0.01,0.05),急性期及恢复期MPP患儿血清TGFβ-1均明显高于对照组(Pa<0.01)。MPP患儿急性期与恢复期IL-10、TGFβ-1无明显差异(Pa>0.05)。结论IL-10低水平表达与MPP发病可能有关,存在炎症反应失控,同时存在以TGFβ-1高水平表达的抗感染反应占优势。Objective To explore the changes of interleukin-10（IL-10） and transforming growth factor-beta 1（TGF-β1）in 26 children with mycoplasma pneumoniae pneumonia（MPP）.Methods Enzyme-linked immunosorbent assay（ELISA） was used to detect the levels of IL-10 and TGF-β1 in the serum of 12 healthy children as normal controls and 26 patients of acute stage as acute stage MPP group,9 of acute stage MPP group in recovery stage as recovery stage MPP group.The levels of IL-10 and TGF-β1 were compared between the three groups.Results IL-10 level in acute stage MPP group was significantly lower than that in normal controls（P〈0.01）,the levels of TGF-β1 in both acute stage and recovery stage MPP group were significantly higher than that in normal controls（Pa〈0.01）.There were no significant differentes of the levels of IL-10 and TGF-β1 between acute stage MPP group and recovery stage MPP group.Conclusions The low level of IL-10 may cause MPP,MPP patients have abnormal inflammatory response,but antiinflammaory responses take the dominate with the high level of TGF-β1.

关 键 词：儿童 肺炎支原体 肺炎 白细胞介素10 转化生长因子-Β1 

分 类 号：R725.6[医药卫生—儿科]