芳香醛和芳香胺参予的Mannich反应及其合成应用  

On Mannich Reactions with aromatic aldehydes and aromatic amines and their application in organic synthesis

作　　者：肖敏[1] 吴筱屏[1] 梁本熹[1] 村松Y 李志良[1] 

机构地区：[1]湖南大学化学化工系,长沙410082 [2]国立技科大学工学院

出　　处：《化学试剂》1997年第1期8-11,共4页Chemical Reagents

基　　金：日本政府文部省资助;国家教委与机械部资助

摘　　要：研究了芳香胺和芳香醛参予的Mannich反应及其合成应用。以它们为原料合成了10余种新的Mannich碱。也使Mannich反应由单一甲醛扩展到芳香醛，产率为623％～90.4％。Mannich reactions with aromatic amines and aromatic aldehydes and their applications were studied systematically. In this paper,a novel type of Mannich reactions with aromatic aldehydes and aromatic amines as well as 2-pentanone were performed at room temperature or slightly below in the presence of concentrated hydrochloric acid as the catalyst. More than ten related Mannich bases, 1-aryl-1-arylamino-3-hexanone, were synthesized with yields 62. 3% ~ 90. 4 %.Among the prepared Mannich bases there are morethan ten new compounds.

关 键 词：MANNICH反应 MANNICH碱 芳香醛 芳香胺 合成 

分 类 号：O625.632[理学—有机化学] O625.4[理学—化学]