鞘内注射生长抑素对炎症痛大鼠痛阈和电针镇痛的影响  

Effects of intrathecal injected somatostatin on pain threshold of adjuvant arthritis rat and electroacupuncture analgesia action

作　　者：吴富东[1] 张永臣[1] 单秋华[2] 王健[1] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医药大学学报》2007年第6期485-487,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助课题(No:30371801)

摘　　要：目的:观察鞘内注射生长抑素对炎症痛大鼠痛阈和电针镇痛效应的影响。方法:将Wister大鼠造模并分组,电针大鼠腰3、腰5华佗夹脊穴,鞘内注射生长抑素及其拮抗剂、纳洛酮和米胺色林,分别测定大鼠的痛阈。结果:鞘内注射生长抑素可提高大鼠的痛阈,并使电针镇痛的效应加强;生长抑素拮抗剂可使大鼠的痛阈降低,并减弱电针镇痛的效应。鞘内注射生长抑素的镇痛作用可被纳洛酮和米胺色林所抑制。结论:生长抑素、电针均有较好的镇痛效果,且有协同镇痛作用;生长抑素可激活阿片肽和5-HT系统的活动而起到镇痛作用,可以增强阿片肽对痛觉信号传导的抑制,起到提高电针镇痛的作用。Objective：to observe the effect of intrathecal injected somatostatin （SS） on pain threshold adjuvant arthritis rat and electroacupuncture（EA） analgesia action. Methods： the Wister rats were divided into 12 groups. Electroacunpuncture group （4/60 Hz, dense-sparse pulses, 1 mA） was applied to bilateral Jiaji （EX-B 2） points of L3 and L5 for 30 mins, once daily, continuously for 7 days. Divided groups were injected SS, SSRA, Naloxone, Mianserin partly. Rat＇s pain thresholds were mensurated. Results： Intrathecal injected SS enhanced rat＇s pain thresholds, and enhanced the effects of EA analgesia. Intrathecal injected SSRA reduced rat＇ s pain thresholds, and reduced the effects of EA analgesia. The analgesia effects of injected SS were depressed by injected Naloxone and Mianserin. Conclusion： SS and EA have preferable analgesia effects, and their analgesia effects may be strengthed mutual. SS can activate opium peptide and 5-HT system, and strength the depressing effects of opium peptide to transferring pain information , and enhance the effects of EA analgesia.

关 键 词：佐剂性关节炎 电针 夹脊穴 镇痛 生长抑素 大鼠 

分 类 号：R245.9[医药卫生—针灸推拿学]