HMM在生物序列分析中的应用  

HMM applications to biological sequences analyzing

作　　者：陈雄峰[1] 

机构地区：[1]闽江学院计算机科学系,福建福州350108

出　　处：《闽江学院学报》2007年第5期52-55,共4页Journal of Minjiang University

摘　　要：阐明HMM的基本理论与概念,进而总结介绍HMM应用的基本问题与算法;重点介绍并分析了可用于表示序列家族的几种HMM结构特点,并说明了利用已知家族Profile HMM构造多序列比对的方法;阐述了常用于基因发现的GHMM和目前常用于发现基因结构的HMM结构特点;最后介绍一种结合多种基因发现工具的HMM主要思想.It clarifies HMM＇s foundational theories and basic concepts, and then summarizes out the basic problems and algorithms of HMM applications. It emphatically introduces and analyzes the structural char-acteristics of some kinds of Profile HMM for modeling sequence families, and illuminates the method of constructing the multi-sequences alignment of the family members by its known Profile HMM. It also expa-tiates the structural characteristics of GHMM that are frequently applied to find gene and a new kind of HMM that is frequently applied to find gene structure in current. And the main idea of a kind of HMM that can combine multiple gene finding tools is finally introduced.

关 键 词：HMM 序列家族 基因发现 

分 类 号：TP301.6[自动化与计算机技术—计算机系统结构]