米卡芬净治疗恶性血液病合并侵袭性真菌病的疗效分析  

Outcome analysis of invasive fungal infections in patients with hematologic malignancy after micafungin treatment

作　　者：周冰新[1] 沈建箴[1] 林艳娟[1] 郭江睿[1] 李静[1] 唐晶晶[1] 

机构地区：[1]福建医科大学附属协和医院福建省血液病研究所,福建福州350001

出　　处：《中国实用内科杂志》2007年第24期1945-1946,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的观查注射用米卡芬净钠治疗恶性血液病合并侵袭性真菌病的疗效。方法2007年2月至10月对福建医科大学附属协和医院福建省血液病研究所12例恶性血液病合并侵袭性真菌病患者，应用注射用米卡芬净钠，剂量100mg／d，分析其疗效、起效时间及不良反应发生率。结果临床总有效率为66．7％，临床诊断病例与拟诊病例有效率分别为57．14％（4／7）和80％（4／5）；临床诊断病例与拟诊病例有效率相比，差异无显著性意义；注射用米卡芬净钠起效时间1～5d。结论注射用米卡芬净钠疗效显著，不良反应少，对恶性血液病合并侵袭性真菌病患者疗效较好。Objective To investigate the efficacy of micafungin sodium for injection in the treatment of invasive fungal infections in patients with hematologic malignancy. Methods The therapeutic effect, action time and adverse effect were analyzed in 12 cases of invasive fungal infections in patients with hematologic malignancy who underwent intravenous injection of micafungin sodium 100 mg qd in Research Center of Hemotology,Union Hospital affiliated to Fujian Medical University,from February 2007 to October 2007. Results The total effective rate was 66. 7%. The effective rates of the patients with clinical diagnosis and with recommended diagnosis were 57. 14% and 80% respectively ;there was no significant difference between them. The mean action time was 1 - 5 days. Conclusion Micafungin sodium for injection is effective and safe in treatment of invasive fungal infections in patients with hematological malignancy.

关 键 词：真菌病 米卡芬净 恶性血液病 

分 类 号：R5[医药卫生—内科学]