地塞米松对室间隔缺损患者介入治疗后cTnI和CRP的影响  

Clinical study of dexamethasone on cTnI and CRP after interventional closure of ventricular septal defects

作　　者：和旭梅[1] 马东江[1] 张玉顺[1] 李寰[1] 代政学[1] 

机构地区：[1]第四军医大学西京医院心血管内科,陕西西安710032

出　　处：《心脏杂志》2007年第6期679-681,共3页Chinese Heart Journal

基　　金：陕西省自然科学基金项目资助(No.2003C2053)

摘　　要：目的观察地塞米松对室间隔缺损(VSD)患者介入治疗后cTnI和CRP的影响。方法选取VSD患者42例,随机分为激素组(术后连续3d静脉注射地塞米松0.3mg/kg)和对照组(未给予地塞米松)。于术前、术后即刻、4、24和72h采血,用ELISA法检测血清cTnI含量及变化,用免疫比浊法检测血清CRP含量及变化。结果①血清cTnI水平术后即刻、4及24h明显升高,两组在术后即刻、4h无显著性差异,24h激素组显著低于对照组(P<0.05);72h激素组降至术前水平,而对照组仍高于术前,两组间差异显著(P<0.05)。②血清CRP水平术后24h较前明显升高,激素组显著低于对照组(P<0.05);激素组72h降至术前水平,而对照组仍高于术前,两组间差异显著(P<0.05)。结论室间隔缺损患者介入治疗术后,地塞米松的使用可减轻心肌损伤,抑制炎症反应。AIM To observe the effects of dexamethasone on cardiac troponin I （cTnI） and C reactive protein （CRP） after interventional closure of ventricular septal defects. METHODS Forty-two ventricular septal defects （ VSD ） were randomly assigned to dexamethasone group [ （ 0.3 mg/（ Kg·d） ] i. v three days in serial） and control group （no dexamethasone given）. All the patients were taken serial blood samples before, immediately after, as well as 4, 24 and 72 h after intervention. The cTnI levels were measured by ELISA and the levels of CRP were detected by immunonephelometric assay. RESULTS ①Serum cTnI levels increased significantly at the end of the operation, as well as 4 h and 24h after the operation. Significant differences were not found between the two groups at the end and 4h after intervention （ P 〉 0.05 ）. However, the elevations at 24 h were more prominent in the control group than those in the dexamethasone group （ P 〈 0.05 ）. ②Serum CRP levels increased significantly at 24 h after the operation. The CRP in the control group was higher compared with that in the dexamethasone group（P〈0.05）. At 72 h, the cTnI and CRP levels in the dexamethasone group lowered down to the levels before operation while operation. CONCLUSION may decrease the myocardial the levels in the control group lowered to the levels higher than those before After interventional closure of ventricular septal defects, the use of hormone damage and inhibit inflammatory reaction.

关 键 词：地塞米松 肌钙蛋白I C反应蛋白 室间隔缺损 介入治疗 

分 类 号：R542.5[医药卫生—心血管疾病]