超声心动图评定雄性Balb/c小鼠心脏形态和功能  

ASSESMENT OF CARDIAC STRUCTURE AND FUNCTION BY ECHOCARDIOGRAPHIC VALUES FOR MALE Balb/c MICE

作　　者：马继政[1,2] 唐晓霞 朱舒舒 吴恒芳 陈相健 许迪 杨笛 张寄南 

机构地区：[1]南京医科大学第一附属医院心血管病研究所,江苏南京210029 [2]解放军理工大学理学院军事系,江苏211101 [3]不详

出　　处：《中国应用生理学杂志》2007年第4期390-393,共4页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金资助项目(30570745);江苏省135重点实验室资助项目(SK200205)

摘　　要：目的:应用超声心动图评定雄性Balb/c小鼠的心脏形态和功能。方法:应用13MHz线控阵超声探头检测27只Balb/c雄性小鼠心脏(周龄:5-7周),超声检测后,进行戊巴比妥麻醉处死分离左室,测量湿重。结果:获得小鼠完整2维超声心动图,并记录雄性小鼠血流动力学参数。用M型超声心动图计算左室重量与左室湿重呈线性相关:y=1.15x+3.26(r=0.80)。结论:超声心动图参数能够评定小鼠的心脏形态和功能。To assess the parameters of cardiac structure and function of male Balb/c mice by the eehocardiography. Methods： A total of 27 male Balb/c mice（from five to seven week old） were examined with a 13-MHz transthoracic linear-array transducer, hearts were removed from mice anesthetized with Butaylone, and the left ventricular（LV） mass were weighed. Results： Complete 2-dimensional echocardiography for cardiac structure and function were obtained. Hemodynamic parameters were recorded. A correlation existed between LV weight（x） and echocardiographic LV mass（y） with the 2D guided M-mode method： y = 1.15x ＋ 3.26, （ r = 0.80）. Conclusion： Echocardiography appears to be a promising approach for noninvasively assessing LV mass and function in mice.

关 键 词：超声心动图 小鼠 左室重量 

分 类 号：R322.1[医药卫生—人体解剖和组织胚胎学] O426[医药卫生—基础医学]