不同来源株香港海鸥形菌药敏试验结果分析  

Analysis of drug resistance on Laribacter hongkongensis isolated from human and freshwater fish

作　　者：任淑华[1] 倪晓平[2] 孙建荣[2] 周田美[1] 查捷[2] 孔庆鑫[2] 赵洪峰[1] 金慧[2] 徐虹[2] 

机构地区：[1]杭州市第一人民医院院感科,浙江杭州310006 [2]杭州市疾病预防控制中心消媒所,浙江杭州310006

出　　处：《中国微生态学杂志》2007年第6期537-538,543,共3页Chinese Journal of Microecology

摘　　要：目的 对分离自社区获得性胃肠炎患者及淡水鱼肠道内的香港海鸥形菌（Laribacter hongkongensis，LH）进行药敏试验，为临床合理使用抗菌药物提供依据。方法 2005年至2006年杭州市第一人民医院肠道门诊从社区获得性胃肠炎患者中分离到4株及2种淡水鱼体内10株LH菌株，计14株，按美国CLSI推荐的纸片扩散法进行药敏试验。结果 药敏结果显示，14株LH菌株对24种常用抗菌药物中的15种药物，分别表现出不同程度的耐药性，耐药率达62．5％；尤其对青霉素、头孢唑啉和头孢哌酮等3种药物，14株LH菌株均为耐药，耐药率为100．0％；其中人体株LHHZ26，对12种药物耐药、1种为中介。LH对3代头孢表现为较高的耐药性，3种头孢药物的耐药率为71．43％～100％；14株LH株对头孢吡肟及头孢哌N／舒巴坦均为敏感。对氨曲南（14．29％）、庆大霉素（7．14％）、复方新诺明（7．14％）的耐药率较低；喹诺酮类、氯霉素、阿米卡星、美罗培南、亚胺培南等药物均敏感。结论 LH菌株对β-内酰胺类药物表现出耐药性，对青霉素类、头孢菌素类药物广泛耐药。建议对LH感染患者喹诺酮类为首选治疗用药。Objective To study the drug resistance of Laribacter hongkongensis （LH） isolated from community-acquired gastroenteritis patients and two kinds of freshwater fish, providing evidence for clinical treatment of this disease. Methods 14 LH strains isolated from 2005 to 2006, 4 human strains of those were isolated from community-acquired gastroenteritis patients in our hospital, and 10 fish strains were isolated from 2 kinds of freshwater fish. The drug resistance test was carded out according on the standard Kirby-Bauer method of CLSI. Results The results showed that 14 strains had different levels resistance to 15 kinds of 24 antibacterial drugs, the rate of drug resistance was 62.5% ; especially, all of 14 strains had resistance to penicillin, cefazolin and cefoperazone, the rate were 100%. The LH strains had resistant to 12 of 24 drugs, and had intermediate to one drug of them. LH strains had high levels to 3rd cephalosporins, the rate of resistance to three kinds of cephalosporihs were 71.43% - 100.0% ; but all of 14 LH strains had susceptible to cefepim and cefoperazone-sulbactam. 14 strains had low resistant to aztreonam（ 14.29% ） ,gentamycin（7.14% ） , SMZco（7.14% ）. All of 14 LH strains had susceptible to qunolones, choromycetin, amikacin, meropenem, imipenem. Conclusions 14 LH strains is generally resistant to β-lactams, including broad-spectrum penicillins and cephalosporins. Qunolones are first choice medicament for community-acquired gastroenteritis with LH germ.

关 键 词：香港海鸥形菌 社区获得性胃肠炎 淡水鱼 药敏试验 

分 类 号：R378.21[医药卫生—病原生物学]