抗生素作用新靶点的发掘策略  

New strategies for finding novel antibacterial targets

作　　者：谢练武[1] 李翔[1] 欧阳永长[1] 姜淑梅[1] 秦岭[1] 

机构地区：[1]中国科学院南海海洋研究所

出　　处：《中国抗生素杂志》2007年第11期641-646,668,共7页Chinese Journal of Antibiotics

基　　金：中国科学院"引进国外杰出人才"(百人计划)项目;广东省科技计划项目(编号2006B36501004)

摘　　要：抗生素的大量使用和滥用所造成的细菌广泛的耐药性迫使科研人员要加速寻找结构新颖的抗生素。抗生素作用靶点的发掘对药物发现非常重要,本文综述了近几年来国际上运用基因组学、基因芯片等现代生物信息学技术,利用细菌体内的各种酶反应与理化特性,发掘抗生素传统作用新靶点如脂肪酸合成酶、非传统作用新靶点如双信号转导调控系统、群体感应器等的研究进展,这对新抗生素的发现具有一定的指导意义。Widespread bacterial drug resistance originated from massive uses and abuses of antibiotics drives drug discovery in a remarkable speed path. At the same time, finding functional target of antibiotics was extremely important to the drug evaluation. Novel targets can be found through modern biological information technology such as gene chip technique and genomies, along with bacterial enzymatic reactions in vivo and the physiological characteristics. In this paper, we summarized some novel antibiotic targets from traditional bacterial functionality and nontraditional domains in these last few years, including fatty acid synthases, two-component signal transduetion systems and quorum-sensing systems. These new research progresses on novel targets will be a positive strength in novel antibiotic discovery.

关 键 词：抗生素 新靶点 耐药性 基因组学 

分 类 号：R37[医药卫生—病原生物学] R978[医药卫生—基础医学]