碳样小单孢菌FIM99-663产生的新抑锈病素  

Neorustmicin produced by M.carbonacea FIM 99-663

作　　者：连云阳[1] 谢阳[1] 魏天恩[1] 程振泰[1] 程元荣[1] 

机构地区：[1]福建省微生物研究所福建省新药(微生物)筛选重点实验室,福州350007

出　　处：《中国抗生素杂志》2007年第11期657-659,681,共4页Chinese Journal of Antibiotics

摘　　要：在筛选新抗真菌抗生素过程中,从福建邵武森林土壤样品中分离得到一株对酵母样真菌有较强抗菌作用的小单孢菌FIM99-663。经分类鉴定为碳样小单孢菌Micromonospora carbonacea FIM99-663。该菌株发酵次级代谢产物含三个抗真菌活性组份,主成份为Fw99-663C组份,经提取、纯化,理化性质、光谱学分析发现它与新抑锈病素(neorustmicin)同质。In the course of screening for new antifungal antibiotics, Micromonospora sp. FIM 99-663 was isolated from a forest soil sample collected in Shaowu, China. Based on the taxonomic data, the strain was identified as Micromonospora carbonacea FIM 99-663. The culture broth of FIM 99-663 contained A, 13 and C three bioactive components, and component A and 13 were traced and major component C was extracted and purified. The physico-chemical properties and spectra of component C showed it was identical with antifungal antibiotic neorustmicin.

关 键 词：小单孢菌 新抑锈病素 抗真菌抗生素 

分 类 号：R978.5[医药卫生—药品]