新药原料——低毒性、抗病毒、抗肿瘤失配双链核糖核酸的研究进展  

Research Development of New Antitumor and Antivirus Material withLow Toxic Side Effect-Mismatched Double Stranded RNAs

作　　者：聂实践[1] 胡冬琴[1] 赵红 罗薇 

机构地区：[1]北京市营养源研究所真菌工程实验室

出　　处：《生物工程进展》1997年第3期10-13,23,共5页Progress in Biotechnology

摘　　要：新药原料——低毒性、抗病毒、抗肿瘤失配双链核糖核酸的研究进展聂实践胡冬琴赵红罗薇（北京市营养源研究所真菌工程实验室）前言近年来，全球性病毒性疾病在不断增加，但对抗病毒药物的研究却进展缓慢。直至今日由病毒引起的恶性疾病（如恶性肿瘤，ＡＩＤＳ病等）仍无法...Double-Stranded RNAs(dsRNA) are inducer of interferon,interleukin 6 and interleukin 2,which can augment human natural killer cell activity and potentiated Lymphokine actived killer cell activity.But dsRNAs are so diverse as to include those which are considered beneficial such as their immunoadjuvant effects as well as those which are considered toxic such as their pyrogenic effects.Mismatched Double-Stranded RNAs are nontoxic analogues of dsRNAs,which can affect human immune respondence without side effects.PolyI:PolyC 12 U is best compared with a lot of Mismatched Double-Stranded RNAs.

关 键 词：药物原料 DSRNA 制备 

分 类 号：TQ460.4[化学工程—制药化工]