芪参活血颗粒在重度脓毒症治疗中的抗炎作用研究  

The Anti-inflammatory Effect of Qishenhuoxue Granule on Severe Sepsis

作　　者：苏艳丽[1] 王红[1] 张淑文[1] 阴赪宏[1] 文艳[1] 王超[1] 王宝恩[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《中国中医急症》2007年第12期1441-1442,1512,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：北京市科委重大项目(No2002-641)

摘　　要：目的观察芪参活血颗粒在重度脓毒症治疗中的抗炎作用,以及对Marshall评分、APACHE Ⅱ评分和住ICU时间的影响。方法110例重度脓毒症患者随机分为单纯西药组(B组,西医常规治疗,52例)与中西医结合组(A组,芪参活血颗粒加西医常规治疗,58例),比较两组之间炎症因子(TNF-α、IL-6、IL-10、IL-6/IL-10等)、Marshall评分、APACHE Ⅱ评分及住ICU时间的差异。结果A组IL-6、TNF-α水平较B组明显下降,住ICU时间较B组明显缩短。结论应用芪参活血颗粒可降低重度脓毒症患者的IL-6、TNF-α水平,并缩短其住ICU时间,在脓毒症治疗方面显示出良好的治疗前景。Objective： To study the anti - inflammatory effect of Qishenhuoxue Granule on severe sepsis, and the influence on calculations of Marshall score ,APACHE Ⅱ score and ICU stay. Methods： 110 patients with severe sepsis or severe trauma from 4 hospital were randomly divided into two groups： 52 in control group （B group） and 58 in herbal group （A group ）. Patients were monitored for changes in laboratory variables （including TNF- α, IL- 6, IL- 10 et al）, and calculations of Marshall score,APACHE H score and the length of stay in ICU. Results： In A group, IL- 6 and TNF- α levels were significantly decreased and the length of stay in ICU was shortened after therapy. Conclusion： The chinese herbal preparation Qishenhuoxue Granule could reduce the blood levels of IL - 6 and TNF - α, shorten the length of stay in ICU, and has significiant therapeutic effects on patients with severe sepsis.

关 键 词：脓毒症 炎症因子 芪参活血颗粒 

分 类 号：R631.2[医药卫生—外科学]