黄芪总黄酮对大鼠实验性心律失常的保护作用  

The protecting effects of totalflavonoids of astragalus (TFA) on experimental arrhythmia in rats

作　　者：赵明[1] 于影[1] 邵慧杰[2] 刘贝贝[2] 

机构地区：[1]内蒙古民族大学附属医院,内蒙古通辽市028000 [2]吉林大学临床医学2系

出　　处：《中国心血管病研究》2007年第12期918-919,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨黄芪总黄酮对大鼠心律失常保护作用的效果和机理。方法采用大鼠心肌缺血再灌注、氯化钡致大鼠心律失常两种动物模型,以BL-420生物机能实验系统观察ECG的相关指标,并进行统计分析。结果①黄芪总黄酮组与对照组相比较,可以使心肌缺血再灌注大鼠模型的室性早搏、室速与对照组相比均有明显减少(8只,P=0.0317)。②黄芪总黄酮组与对照组相比较,可以使氯化钡致大鼠心律失常两种动物模型的心律失常明显减轻(8只,P=0.02863)。结论黄芪总黄酮对大鼠心肌缺血再灌注和氯化钡诱发的心律失常具有保护作用。Objective To study the effect of totalflavonoids of astragalus （TFA） on experimental arrhythmia in Rats, Methods Arrhythmia model which was induced by barium chloride and creating myocardial ischemic reperfusion were applied to compare the effect of TFA with the control on arrhythmogenesis of the model Rats; Results （1）TFA could decrease the arrhythmogenesis of the rats of ischamia reperfusion compared with control （n=8,P=0.0317）. （2）TFA could decrease arrhythmogenesis of the rats induced by barium chloride （n=8,P= 0.02863 ）. Conclusion TFA has a remarkable protecting effect on experimental arrhythmia in Rats.

关 键 词：黄芪属植物 黄酮类 再灌注损伤 心律失常 缺血预处理 

分 类 号：Q95-33[生物学—动物学] R541.7[医药卫生—心血管疾病]