急性冠状动脉综合征后焦虑与血浆炎症因子相关性分析  

The relation between post-acute coronary syndrome anxiety and serum levels of inflammatory factors

作　　者：张俊蒙[1] 马文林[1] 徐颖[1] 李美婧[1] 赵明中[1] 邢燕[1] 朱梦云[1] 胡大一[2] 

机构地区：[1]上海同济大学心肺血管中心,200092 [2]北京大学人民医院心脏中心

出　　处：《中华内科杂志》2007年第12期1022-1024,共3页Chinese Journal of Internal Medicine

摘　　要：目的探讨血浆炎症因子在急性冠状动脉综合征(ACS)后焦虑发病中的作用。方法检测101例 ACS 住院患者发病72 h 内血浆 IL-6、TNFα、超敏 C 反应蛋白(hsCRP)水平,同时并完成标准化问卷调查表《医院焦虑抑郁量表-焦虑分表》并计分,并记录患者的人口统计学资料。结果ACS 后焦虑与非焦虑患者的血浆 TNFα水平差异有统计学意义(M=0.68 pg/ml,焦虑组与对照组平均秩次44.55比61.70,P=0.004),而血浆 hsCRP、IL-6水平在两组中差异无统计学意义。结论ACS 后焦虑不增加患者体内的炎症反应。Objective To explore the role of inflammatory factors （interleukin-6, tumor necrosis factor alpha,high sensitive C reactive protein） in the pathogenesis of anxiety after acute coronary syndrome （ACS） by investigating the serum levels of interleukin-6 （IL-6）, tumor necrosis factor alpha（TNFα）and high sensitive C reactive protein （hsCRP）. Methods Serum IL-6, TNFαand hsCRP levels were measured in 105 ACS patients within 7 days after onset of the event. Symptoms of anxiety were evaluated by self- reporting standardized questionnaire, using a validated Chinese version of Hospital Anxiety and Depression Scale （HADS-A）-Anxiety Subscale （7 items） within 72 hours of the event. Demographic and clinical data including cardiac risk factors were recorded. Results The median of TNFα was lower in the anxious patients with ACS than that of non-anxious ones （44. 55 vs 61.70, P =0. 004）. Neither the levels of hsCRP nor the levels of IL-6 were found to be different between the groups with anxiety and without. Conclusion Anxiety after ACS does not increase the inflammatory reaction in the ACS patients.

关 键 词：冠状动脉疾病 焦虑 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]