细菌外排机制及其抑制剂研究进展  

Research Progress in the Mechanism of Bacterial Efflux Pumps and the Development of Potential Efflux Inhibitors

作　　者：夏红灯[1] 徐元宏[1] 

机构地区：[1]安徽医科大学第一附属医院检验科,合肥230022

出　　处：《国外医药（抗生素分册）》2007年第6期259-263,269,共6页World Notes on Antibiotics

摘　　要：细菌耐药性,尤其是多重耐药问题日益严重,给临床治疗带来极大的困难。而细菌外排机制是细菌产生多重耐药的重要机制之一。本文对细菌外排泵系统的组成、种类和几种常见耐药病原菌(包括大肠埃希菌、铜绿假单胞菌和金葡菌)中的主要外排泵,以及外排泵抑制剂的研究进展作简要综述。The mechanism of bacterial efflux pumps is one of the important factors resulting in bacterial multidrug resistance. This paper aims to review the categories and composition of bacterial efflux pumps, mainly summarizes the mechanisms of the efflux pumps found in a number of common pathogenic bacteria including Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The progress in the development of efflux pump inhibitors is also described.

关 键 词：耐药 外排泵 外排泵抑制剂 

分 类 号：R978[医药卫生—药品]